Parsons Cameron, Lee Sangmi, Kathariou Sophia
Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, NC 27695-7624, USA.
Seoul National University, Seoul 08826, Korea.
Genes (Basel). 2018 Dec 24;10(1):11. doi: 10.3390/genes10010011.
is ubiquitous in the environment and causes the disease listeriosis. Metal homeostasis is one of the key processes utilized by in its role as either a saprophyte or pathogen. In the environment, as well as within an animal host, needs to both acquire essential metals and mitigate toxic levels of metals. While the mechanisms associated with acquisition and detoxification of essential metals such as copper, iron, and zinc have been extensively studied and recently reviewed, a review of the mechanisms associated with non-essential heavy metals such as arsenic and cadmium is lacking. Resistance to both cadmium and arsenic is frequently encountered in , including isolates from human listeriosis. In addition, a growing body of work indicates the association of these determinants with other cellular functions such as virulence, suggesting the importance of further study in this area.
在环境中普遍存在，并导致李斯特菌病。金属稳态是其作为腐生菌或病原体发挥作用时所利用的关键过程之一。在环境以及动物宿主体内，它既需要获取必需金属，又要减轻金属的毒性水平。虽然与铜、铁和锌等必需金属的获取和解毒相关的机制已得到广泛研究且近期有综述，但缺乏对与砷和镉等非必需重金属相关机制的综述。在该菌中经常遇到对镉和砷的抗性，包括来自人类李斯特菌病的分离株。此外，越来越多的研究表明这些决定因素与其他细胞功能如毒力有关，这表明在该领域进一步研究的重要性。
