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植物病毒感染中的自噬作用。

Autophagy in plant viral infection.

机构信息

MOE Key Laboratory of Bioinformatics, Center for Plant Biology, School of Life Sciences, Tsinghua University, Beijing, China.

Tsinghua-Peking Center for Life Sciences, Beijing, China.

出版信息

FEBS Lett. 2022 Sep;596(17):2152-2162. doi: 10.1002/1873-3468.14349. Epub 2022 Apr 24.

Abstract

Autophagy is a conserved degradation pathway that delivers dysfunctional cellular organelles or other cytosol components to degradative vesicular structures (vacuoles in plants and yeasts, lysosomes in mammals) for degradation and recycling. Viruses are intracellular parasites that hijack their host to live. Research on regulation of the trade-off between plant cells and viruses has indicated that autophagy is an integral part of the host response to virus infection. Meanwhile, plants have evolved a diverse array of defense responses to counter pathogenic viruses. In this review, we focus on the roles of autophagy in plant virus infection and offer a glimpse of recent advances about how plant viruses evade autophagy or manipulate host autophagy pathways to complete their replication cycle.

摘要

自噬是一种保守的降解途径,可将功能失调的细胞细胞器或其他胞质成分递送至降解性囊泡结构(植物和酵母中的液泡,哺乳动物中的溶酶体)进行降解和再循环。病毒是劫持宿主生存的细胞内寄生虫。对植物细胞和病毒之间权衡的调节研究表明,自噬是宿主对病毒感染反应的一个组成部分。同时,植物已经进化出多种防御反应来对抗致病性病毒。在这篇综述中,我们重点介绍自噬在植物病毒感染中的作用,并简要介绍最近关于植物病毒如何逃避自噬或操纵宿主自噬途径以完成其复制周期的进展。

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