Singh Kshitij R B, Natarajan Arunadevi
Department of Chemistry, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Department of Chemistry, PSGR Krishnammal College for Women, Coimbatore, Tamil Nadu, India.
Luminescence. 2023 Jul;38(7):834-844. doi: 10.1002/bio.4252. Epub 2022 Apr 26.
Molecularly imprinted polymers (MIPs) are artificial antibodies for a target molecule. The review focuses mainly on mechanistic steps involved in forming MIPs and the role of co-monomers and porogen. In addition, the electronic transition between different energy levels is explained with the help of the Jablonski diagram. Diverse receptor and target molecules for anchoring artificial MIPs are discussed, accentuating the synergetic effects obtained. The binding efficiency, selectivity, and sensitivity of various optical sensors are discussed intensively. In addition to this, we focused on synthesis, physical forms, characterization techniques, and microorganism detection of imprinted polymers. A brief investigation on the use of MIPs in cancer diagnosis is also included, and attention is extended to the important challenges faced in using imprinted polymers.
分子印迹聚合物（MIPs）是针对目标分子的人工抗体。本综述主要关注形成MIPs所涉及的机理步骤以及共聚单体和致孔剂的作用。此外，借助雅布隆斯基图解释了不同能级之间的电子跃迁。讨论了用于锚定人工MIPs的多种受体和目标分子，强调了所获得的协同效应。深入讨论了各种光学传感器的结合效率、选择性和灵敏度。除此之外，我们重点关注了印迹聚合物的合成、物理形态、表征技术和微生物检测。还包括对MIPs在癌症诊断中的应用的简要研究，并将注意力扩展到使用印迹聚合物时面临的重要挑战。
