Du Wenzhen, Zhang Lijing, Li Xiaodan, Ling Guixia, Zhang Peng
Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China.
Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China.
Int J Pharm. 2022 May 10;619:121735. doi: 10.1016/j.ijpharm.2022.121735. Epub 2022 Apr 9.
With the exponential growth of nanomedicine research, subcellular-delivery nanosystems (SDNSs) has rapidly become a research focus, which suggests that the idea of curing cancer may not be a pipe dream. As the center of genetic material storage, replication, and transcription, the nucleus can be regarded as the final target of many cancer treatment methods. Thus, nuclear-targeted SDNSs may have clinical potential for precise cancer treatment by delivering therapeutic agents and assisting various treatment methods. Herein, the latest progress of nuclear-targeted SDNSs for cancer treatment are reviewed and listed. Additionally, the possible mechanisms of SDNSs entering the nucleus and its applications in the field of cancer treatment as well as some typical preparations are summarized and the exciting future of SDNSs is also briefly highlighted.
随着纳米医学研究的指数级增长，亚细胞递送纳米系统（SDNSs）迅速成为研究热点，这表明治愈癌症的想法或许并非遥不可及。作为遗传物质储存、复制和转录的中心，细胞核可被视为许多癌症治疗方法的最终靶点。因此，核靶向SDNSs通过递送治疗剂并辅助各种治疗方法，可能具有精确治疗癌症的临床潜力。在此，对用于癌症治疗的核靶向SDNSs的最新进展进行综述和列举。此外，总结了SDNSs进入细胞核的可能机制及其在癌症治疗领域的应用以及一些典型制剂，并简要展望了SDNSs令人振奋的未来。
