İzmir Tınaztepe University, Faculty of Health Sciences, İzmir, Turkey.
Necmettin Erbakan University, Faculty of Health Sciences, Konya, Turkey.
Am J Otolaryngol. 2022 May-Jun;43(3):103428. doi: 10.1016/j.amjoto.2022.103428. Epub 2022 Apr 6.
It is thought that COVID-19 may cause hearing loss, but its effects on the hearing system are not clear. This study aimed to reveal the effects of COVID-19 on the auditory system by using various audiological measurement methods in individuals diagnosed with COVID-19.
Thirty individuals between the ages of 18-45, who were diagnosed with COVID-19 by PCR at least one month ago, and had no pre-COVID-19 hearing loss complaints, constituted the test group. Thirty individuals aged between 18 and 30 years and who had no history of hearing loss constituted the control group. Audiological evaluations of all participants were made with pure-tone audiometry, high-frequency audiometry, transient-evoked otoacoustic emission (TEOAE), distortion product otoacoustic emission (DPOAE), and auditory brainstem response (ABR) measurements.
A significant difference was found between the groups at all high frequencies between 4 and 14 kHz (p < 0.05). TEOAE amplitudes at 1500 Hz, 2000 Hz and 4000 Hz frequencies and DPOAE amplitudes at 4003 Hz and higher frequencies were significantly lower in the test group (p < 0.05). While there was a significant difference between the I, III and V absolute latencies between the groups (p < 0.05), there was no significant difference between the I-III, III-V and I-V interpeak latencies (p > 0.05) as a result of the ABR test.
This study showed that COVID-19 can cause cochlear damage, especially at high frequencies. More studies are needed to determine the effects of COVID-19 on the auditory system.
人们认为 COVID-19 可能导致听力损失,但 COVID-19 对听力系统的影响尚不清楚。本研究旨在通过使用各种听力学测量方法,揭示 COVID-19 对已确诊 COVID-19 个体的听觉系统的影响。
本研究纳入了年龄在 18-45 岁之间、至少一个月前通过 PCR 确诊 COVID-19 且无 COVID-19 前听力损失投诉的 30 名个体作为实验组。年龄在 18-30 岁之间且无听力损失史的 30 名个体作为对照组。对所有参与者进行纯音测听、高频测听、瞬态诱发耳声发射(TEOAE)、畸变产物耳声发射(DPOAE)和听性脑干反应(ABR)测量。
两组在 4-14 kHz 的所有高频范围内均存在显著差异(p<0.05)。实验组 1500 Hz、2000 Hz 和 4000 Hz 频率的 TEOAE 振幅和 4003 Hz 及更高频率的 DPOAE 振幅显著降低(p<0.05)。虽然两组的 I、III 和 V 绝对潜伏期之间存在显著差异(p<0.05),但 ABR 测试中 I-III、III-V 和 I-V 峰间潜伏期之间无显著差异(p>0.05)。
本研究表明 COVID-19 可引起耳蜗损伤,尤其是高频听力损失。需要更多的研究来确定 COVID-19 对听觉系统的影响。