Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Canada.
Can J Neurol Sci. 2022 Mar;49(2):184-195. doi: 10.1017/cjn.2021.63. Epub 2021 Apr 12.
Extensive studies indicate that severe acute respiratory syndrome coronavirus (SARS-CoV-2) involves human sensory systems. A lack of discussion, however, exists given the auditory-vestibular system involvement in CoV disease 2019 (COVID-19). The present systematic review and meta-analysis were performed to determine the event rate (ER) of hearing loss, tinnitus, and dizziness caused by SARS-CoV-2.
Databases (PubMed, ScienceDirect, Wiley) and World Health Organization updates were searched using combined keywords: 'COVID-19,' 'SARS-CoV-2,' 'pandemic,' 'auditory dysfunction,' 'hearing loss,' 'tinnitus,' 'vestibular dysfunction,' 'dizziness,' 'vertigo,' and 'otologic symptoms.'
Twelve papers met the eligibility criteria and were included in the study. These papers were single group prospective, cross-sectional, or retrospective studies on otolaryngologic, neurologic, or general clinical symptoms of COVID-19 and had used subjective assessments for data collection (case histories/medical records). The results of the meta-analysis demonstrate that the ER of hearing loss (3.1%, CIs: 0.01-0.09), tinnitus (4.5%, CIs: 0.012-0.153), and dizziness (12.2%, CIs: 0.070-0.204) is statistically significant in patients with COVID-19 (Z ≤ -4.469, p ≤ 0.001).
COVID-19 can cause hearing loss, tinnitus, and dizziness. These findings, however, should be interpreted with caution given insufficient evidence and heterogeneity among studies. Well-designed studies and follow-up assessments on otologic symptoms of SARS-CoV-2 using standard objective tests are recommended.
大量研究表明，严重急性呼吸综合征冠状病毒（SARS-CoV-2）涉及人体感觉系统。然而，由于 COVID-19 与听觉-前庭系统的关系尚未得到充分讨论。本系统评价和荟萃分析旨在确定 SARS-CoV-2 引起的听力损失、耳鸣和头晕的发生率（ER）。
使用组合关键字在数据库（PubMed、ScienceDirect、Wiley）和世界卫生组织更新中搜索：“COVID-19”、“SARS-CoV-2”、“大流行”、“听觉功能障碍”、“听力损失”、“耳鸣”、“前庭功能障碍”、“头晕”、“眩晕”和“耳科症状”。
符合入选标准的 12 篇论文被纳入研究。这些论文是关于 COVID-19 的耳鼻喉科、神经科或一般临床症状的单组前瞻性、横断面或回顾性研究，并且使用主观评估进行数据收集（病史/病历）。荟萃分析的结果表明，COVID-19 患者听力损失（3.1%，CI：0.01-0.09）、耳鸣（4.5%，CI：0.012-0.153）和头晕（12.2%，CI：0.070-0.204）的发生率具有统计学意义（Z ≤ -4.469，p ≤ 0.001）。
COVID-19 可引起听力损失、耳鸣和头晕。然而，鉴于研究之间证据不足且存在异质性，这些发现应谨慎解释。建议使用标准客观测试对 SARS-CoV-2 的耳科症状进行设计良好的研究和随访评估。
