Wang Shuncong, Chen Lei, Feng Yuanbo, Swinnen Johan V, Jonscher Charles, Van Ongeval Chantal, Ni Yicheng
Theragnostic Laboratory, KU Leuven, Biomedical Group, Campus Gasthuisberg, 3000 Leuven, Belgium.
Laboratory of Lipid Metabolism and Cancer, KU Leuven, Biomedical Group, Campus Gasthuisberg, 3000 Leuven, Belgium.
Cancers (Basel). 2022 Mar 22;14(7):1608. doi: 10.3390/cancers14071608.
The epidemiology and associated potential heterogeneity of synchronous lung metastasis (sLM) have not been reported at a population-based level. Cancer patients with valid information about sLM status in the Surveillance, Epidemiology, and End Results database were enrolled. The prevalence of sLM, with a 95% confidential interval, and median survival of sLM, with interquartile range, were calculated and compared by Chi-square analyses and log-rank tests by primary cancer type and clinicopathological factors. Furthermore, the risk factors of sLM development were identified by multivariate logistic regression. Among 1,672,265 enrolled cases, 3.3% cases were identified with sLM, with a median survival of 7 months. Heterogeneity in prevalence and prognosis in sLM was observed among different primary cancers, with the highest prevalence in main bronchus cancer and best survival in testis cancer. Higher prevalence and poorer prognosis were observed in the older population, male population, African American, patients with lower socioeconomic status, and cases with advanced T stage, N stage, or more malignant pathological characteristics. Race, age, T stage, N stage, metastasis to other sites, insurance status and marital status were associated with sLM development (p < 0.001). The current study highlights the heterogeneity of the prevalence and prognosis in patients with sLM.
基于人群水平的同步性肺转移（sLM）的流行病学及相关潜在异质性尚未见报道。本研究纳入了监测、流行病学和最终结果数据库中具有sLM状态有效信息的癌症患者。通过卡方分析和对数秩检验，按原发癌类型和临床病理因素计算并比较了sLM的患病率（95%置信区间）和sLM的中位生存期（四分位间距）。此外，通过多因素逻辑回归确定了sLM发生的危险因素。在1672265例纳入病例中，3.3%的病例被诊断为sLM，中位生存期为7个月。不同原发癌之间观察到sLM患病率和预后的异质性，主支气管癌患病率最高，睾丸癌生存期最佳。老年人群、男性人群、非裔美国人、社会经济地位较低的患者以及T分期、N分期较晚或病理特征恶性程度更高的病例中，sLM患病率更高且预后更差。种族、年龄、T分期、N分期、其他部位转移、保险状况和婚姻状况与sLM的发生相关（p<0.001）。本研究突出了sLM患者患病率和预后的异质性。
