Cui Pengfei, Cong Xiaofeng, Zhang Youhao, Zhang Huimin, Liu Ziling
Cancer Center, The First Hospital of Jilin University, Changchun, China.
Front Oncol. 2022 Oct 24;12:961155. doi: 10.3389/fonc.2022.961155. eCollection 2022.
A systematic analysis of prognostic factors concerning endometrial clear cell carcinoma (ECCC) is lacking. The current study aimed to construct nomograms predicting the overall survival (OS) of ECCC patients.
We performed a retrospective study, and predicted nomograms for 3-, 5-, and 10-year OS were established. The nomograms were verified with the consistency index (C-index), calibration curve, and decision curve analysis (DCA).
A total of 1778 ECCC patients, 991 from FIGO stage I/II and 787 from FIGO stage III/IV, were included in this study. The age at diagnosis, marital status, T stage, tumor size, and surgery-independent prognostic factors in FIGO stage I/II, and the age at diagnosis, T stage, lymph node involvement, distant metastasis, tumor size, surgery, radiotherapy, and chemotherapy in FIGO stage III/IV were independent prognostic factors. The C-indexes of the training and validation group were 0.766 and 0.697 for FIGO stage I/II and 0.721 and 0.708 for FIGO stage III/IV, respectively. The calibration curve revealed good agreement between nomogram-predicted and actual observation values. The DCA established that nomograms had better clinical benefits than the traditional FIGO stage.
The predicted nomograms showed good accuracy, excellent discrimination ability, and clinical benefits, depicting their usage in clinical practice.
目前缺乏对子宫内膜透明细胞癌（ECCC）预后因素的系统分析。本研究旨在构建预测ECCC患者总生存期（OS）的列线图。
我们进行了一项回顾性研究，并建立了3年、5年和10年总生存期的预测列线图。通过一致性指数（C指数）、校准曲线和决策曲线分析（DCA）对列线图进行验证。
本研究共纳入1778例ECCC患者，其中991例为国际妇产科联盟（FIGO）I/II期，787例为FIGO III/IV期。诊断时年龄、婚姻状况、T分期、肿瘤大小以及FIGO I/II期的非手术相关预后因素，和FIGO III/IV期的诊断时年龄、T分期、淋巴结转移、远处转移、肿瘤大小、手术、放疗和化疗均为独立预后因素。FIGO I/II期训练组和验证组的C指数分别为0.766和0.697，FIGO III/IV期分别为0.721和0.708。校准曲线显示列线图预测值与实际观察值之间具有良好的一致性。DCA表明列线图比传统的FIGO分期具有更好的临床效益。
预测列线图显示出良好的准确性、出色的辨别能力和临床效益，表明其在临床实践中的应用价值。
