Mechanistic aspects on chemical induction of spindle disturbances and abnormal chromosome numbers.

Work on the chemical induction of spindle disturbances and abnormal chromosome numbers, and work on the composition and biochemistry of the spindle are reviewed. Some early investigations have shown that there is an unspecific mechanism for chemical induction of spindle disturbances. This mechanism is based on the interaction of compounds with cellular hydrophobic compartments. Some compounds act differently and are more active than predicted from their lipophilic character. Selected compounds of that kind and their possible mechanisms of action are discussed. Changes in sulfhydryl and ATP levels, oxidative damage of membranes and impaired control of cytoplasmic Ca2+ levels are discussed in this context.