Infective Endocarditis by Species: A Systematic Review.

is the most clinically relevant species among spp. For decades, it was considered to be part of the normal human flora in the upper respiratory tract. However, since the late 1970s, considerable evidence has proposed that is an important pathogen in the human respiratory tract. Even though Infective Endocarditis (IE) is rarely caused by spp., these infections can be problematic due to the lack of experience in their management. The aim of this study was to systematically review all published cases of IE by spp. A systematic review of PubMed, Scopus and Cochrane library (through 8 December 2021) for studies providing epidemiological, clinical, microbiological data as well as treatment data and outcomes of IE by spp. was performed. A total of 27 studies, containing data for 31 patients, were included. A prosthetic valve was present in 25.8%. Mitral valve was the most commonly infected site. Fever, sepsis and embolic phenomena were the most common clinical presentations. Cephalosporins, aminoglycosides, aminopenicillins and penicillin were the most commonly used antimicrobials. Overall mortality was 12.9%.