De Leo Vincenzo, Tosti Claudia, Morgante Giuseppe, Ponchia Rosetta, Luddi Alice, Governini Laura, Piomboni Paola
Department of Molecular and Developmental Medicine, Siena University, 53100 Siena, Italy.
Assisted Reproduction Unit, Siena University Hospital, 53100 Siena, Italy.
J Clin Med. 2022 Apr 2;11(7):1991. doi: 10.3390/jcm11071991.
Oligoasthenoteratozoospermia (OAT) accounts for about 90% of male infertility; in many cases this disorder may be associated with oxidative stress, a condition that decreases the success of fertilization. Therefore, the empirical treatment of male infertility is often based on the use of antioxidants. The aim of the present study was to assess the effectiveness of three months' administration of a new nutraceutical preparation on hormone profile, sperm parameters and fertilization capability in men undergoing in vitro fertilization (IVF). A total of 36 OAT patients were daily treated for 3 months with a dose of a formulation containing: Inositol, L-Carnitine, Vitamins C, D, E, Coenzyme Q10 and Selenium. Selected parameters were analysed before (T0) and after (T1) treatment, and IVF outcomes were evaluated. We observed an improvement of sperm concentration, motility, morphology and vitality; blood level of testosterone also showed an increase. A significant increase of fertilization rate was detected in 14 couples, whose male partner were treated with the nutraceutical preparation. The present results indicate that a formulation containing antioxidant and energy supply substances was effective in the treatment of sperm alterations and led to significant recovery of fertilizing capacity.
少弱畸精子症（OAT）约占男性不育症的90%；在许多情况下，这种病症可能与氧化应激有关，氧化应激会降低受精成功率。因此，男性不育症的经验性治疗通常基于使用抗氧化剂。本研究的目的是评估一种新的营养制剂三个月给药对接受体外受精（IVF）男性的激素水平、精子参数和受精能力的有效性。总共36名OAT患者每天服用一剂含有以下成分的制剂进行为期3个月的治疗：肌醇、左旋肉碱、维生素C、D、E、辅酶Q10和硒。在治疗前（T0）和治疗后（T1）分析选定的参数，并评估IVF结果。我们观察到精子浓度、活力、形态和活力有所改善；睾酮的血液水平也有所升高。在14对夫妇中检测到受精率显著提高，这些夫妇的男性伴侣接受了营养制剂治疗。目前的结果表明，一种含有抗氧化剂和能量供应物质的制剂在治疗精子异常方面有效，并导致受精能力显著恢复。
