Ghaemi Marjan, Seighali Niloofar, Shafiee Arman, Beiky Maryam, Kohandel Gargari Omid, Azarboo Alireza, Shafti Vida, Jafarabady Kyana, Eshraghi Nasim, Haddadi Mohammad, Akbari Razieh, Panahi Zahra, Hantoushzadeh Sedigheh
Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute Tehran University of Medical Sciences Tehran Iran.
Student Research Committee, School of Medicine Alborz University of Medical Sciences Karaj Iran.
Food Sci Nutr. 2024 Sep 12;12(11):8515-8524. doi: 10.1002/fsn3.4427. eCollection 2024 Nov.
Myo-inositol may be efficient to improve sperm parameters to increase the chance of fertility. Although, the data are controversial. This study aimed to assess the impact of Myo-inositol supplements on semen quality and in vitro fertilization (IVF) outcomes. In this systematic review and meta-analysis, a comprehensive search was conducted in PubMed, Web of Science, and Embase. The objective was to identify relevant human studies that investigated the effects of Myo-inositol treatment on various sperm factors, such as sperm motility, sperm concentration, sperm morphology, viable spermatozoa, spermatozoa with DNA fragmentation, and pregnancy rate. Additionally, the testosterone levels of patients with Oligo-astheno-teratozoospermia (OAT) after Myo-inositol application were considered. The findings of 16 selected studies from 2240 citations indicated significant improvements in several parameters of sperm after Myo-inositol administration. Myo-inositol treatment was associated with a notable increase in total sperm motility (SMD 0.90; 95% CI: 0.34 to 1.46; = 0%, = .001) and progressive sperm motility (SMD 1.48; 95% CI: 0.37 to 2.59; = 0%, = .008). Additionally, there was a significant improvement in testosterone levels (SMD 0.54; 95% CI: 0.34 to 0.73; = 0%, < .0001). Furthermore, Myo-inositol therapy demonstrated a significant decrease in spermatozoa with DNA fragmentation (SMD -1.37; 95% CI: -2.43 to -0.32; = 85%, = .01). This study suggests that Myo-inositol therapy has a positive impact on specific sperm parameters, such as total and progressive sperm motility, along with testosterone levels. These findings provide support for the potential benefits of Myo-inositol in improving male fertility parameters related to sperm factors.
肌醇可能有助于改善精子参数，增加受孕几率。不过，相关数据存在争议。本研究旨在评估补充肌醇对精液质量和体外受精（IVF）结局的影响。在这项系统评价和荟萃分析中，我们在PubMed、科学网和Embase进行了全面检索。目的是确定相关的人体研究，这些研究调查了肌醇治疗对各种精子因素的影响，如精子活力、精子浓度、精子形态、活精子、有DNA碎片的精子以及妊娠率。此外，还考虑了少弱畸精子症（OAT）患者在应用肌醇后的睾酮水平。从2240篇文献中筛选出的16项研究结果表明，服用肌醇后精子的几个参数有显著改善。肌醇治疗与总精子活力显著增加相关（标准化均数差[SMD] 0.90；95%置信区间[CI]：0.34至1.46；异质性检验I² = 0%，P = 0.001）以及前向运动精子活力显著增加相关（SMD 1.48；95% CI：0.37至2.59；I² = 0%，P = 0.008）。此外，睾酮水平有显著改善（SMD 0.54；95% CI：0.34至0.73；I² = 0%，P < 0.0001）。此外，肌醇治疗显示有DNA碎片的精子显著减少（SMD -1.37；95% CI：-2.43至-0.32；I² = 85%，P = 0.01）。本研究表明，肌醇治疗对特定的精子参数有积极影响，如总精子活力和前向运动精子活力，以及睾酮水平。这些发现为肌醇在改善与精子因素相关的男性生育参数方面的潜在益处提供了支持。
