ISOF, Consiglio Nazionale delle Ricerche, 40129 Bologna, Italy.
Center of Advanced Technologies, Adam Mickiewicz University, 61-712 Poznań, Poland.
Molecules. 2022 Mar 22;27(7):2042. doi: 10.3390/molecules27072042.
Some of the most interesting aspects of free radical chemistry that emerged in the last two decades are radical enzyme mechanisms, cell signaling cascades, antioxidant activities, and free radical-induced damage of biomolecules. In addition, identification of modified biomolecules opened the way for the evaluation of in vivo damage through biomarkers. When studying free radical-based chemical mechanisms, it is very important to establish biomimetic models, which allow the experiments to be performed in a simplified environment, but suitably designed to be in strict connection with cellular conditions. The 28 papers (11 reviews and 17 articles) published in the two Special Issues of on "Biomimetic Radical Chemistry and Applications (2019 and 2021)" show a remarkable range of research in this area. The biomimetic approach is presented with new insights and reviews of the current knowledge in the field of radical-based processes relevant to health, such as biomolecular damages and repair, signaling and biomarkers, biotechnological applications, and novel synthetic approaches.
过去二十年中，自由基化学中出现的一些最有趣的方面是自由基酶机制、细胞信号级联、抗氧化活性以及自由基引起的生物分子损伤。此外，修饰生物分子的鉴定为通过生物标志物评估体内损伤开辟了道路。在研究基于自由基的化学机制时，建立仿生模型非常重要，这使得实验可以在简化的环境中进行，但设计合理，与细胞条件严格相关。在关于“仿生自由基化学及其应用”的两期特刊中发表的 28 篇论文（11 篇综述和 17 篇文章）展示了该领域的广泛研究。仿生方法提出了新的见解，并对与健康相关的基于自由基的过程领域的当前知识进行了综述，例如生物分子损伤和修复、信号和生物标志物、生物技术应用以及新的合成方法。
