Taylor-Robinson D
Pediatr Infect Dis. 1986 Nov-Dec;5(6 Suppl):S262-5. doi: 10.1097/00006454-198611010-00012.
The involvement of Ureaplasma urealyticum in male infertility has been suggested in 10 studies in which strains were found more often in the semen of infertile than fertile men and/or were associated with poor motility or other abnormalities. In contrast these findings have not been supported by those of an equal number of other studies. Ureaplasmas adhere to sperm and therefore have an opportunity to affect them. The numbers of organisms present in semen samples suggest that such a direct effect is unlikely but the question of whether metabolic byproducts affect sperm and whether ureaplasmas cause structural damage to the male genital tract remains unanswered. Ureaplasmas have been isolated from the genital tracts of women of infertile couples more often than from those of women of fertile couples by some but not all investigators and antibiotic therapy has also provided conflicting results. Two groups of workers have reported improvements in sperm motility and quality and increased conception rates in couples rendered Ureaplasma-negative by tetracycline administration. Such observations are provocative but have to be viewed against the failure of other investigators to note similar improvements in conception rates in studies where some attention was paid to controlling them. It should be noted, however, that the beneficial effect of an antibiotic may not be seen clearly if ureaplasmas are responsible for only a small subset of infertility cases.
10项研究表明解脲脲原体与男性不育有关，在这些研究中，不育男性精液中该菌株的检出率高于生育男性，和/或与精子活力差或其他异常有关。相比之下，同样数量的其他研究并未支持这些发现。脲原体可黏附于精子，因此有机会对其产生影响。精液样本中存在的微生物数量表明这种直接影响不太可能，但代谢副产物是否影响精子以及脲原体是否对男性生殖道造成结构损伤的问题仍未得到解答。一些（但并非所有）研究者从不育夫妇女性生殖道中分离出脲原体的频率高于生育夫妇女性，抗生素治疗的结果也相互矛盾。两组研究人员报告称，通过给予四环素使脲原体转阴的夫妇，精子活力和质量有所改善，受孕率提高。这些观察结果颇具启发性，但鉴于其他研究者在一些注重对照的研究中未注意到受孕率有类似改善，因此必须谨慎看待。然而，应该注意的是，如果脲原体仅导致一小部分不育病例，抗生素的有益效果可能并不明显。
