Jagiellonian University Medical College, Faculty of Medicine, Chair of Microbiology, Department of Molecular Medical Microbiology, Cracow, Poland.
Jagiellonian University Medical College, Faculty of Medicine, Chair of Epidemiology and Preventive Medicine, Department of Epidemiology, Cracow, Poland.
Pol J Microbiol. 2022 Feb 27;71(1):19-26. doi: 10.33073/pjm-2022-001.
Genital tract ureaplasma infections are associated with numerous complications, ranging from inflammation, through infertility, to problematic pregnancy. In the course of ureaplasma infection, the risk of human papillomavirus infection increases. Diagnostic tests for urea-plasma infections are not always carried out, especially in women with the normal Nugent test results. The study attempts to check whether it is possible to find a prognostic indicator that could suggest a high abundance of ureaplasmas (≥ 10 CFU/ml) at the stage of the initial examination of vaginal discharge. Such a prognostic factor could qualify women for further tests to detect infections with these atypical bacteria. Six hundred twenty-seven white women with a score of 0-3 on the Nugent scale were tested, including 322 patients with a high abundance of ureaplasmas (≥ 10 CFU/ml) and 305 who tested negative for these bacteria. Ureaplasma infections were detected statistically significant in women who had few or no epithelial cells in the genital swab specimens compared to the results obtained for women with numerous or very numerous epithelial cells ( < 0.001). The risk of the high density of ureaplasmas was 38.7% higher with fewer or no epithelial cells than with high numbers. In patients aged 18-40 years with few or no epithelial cells, a high density of ureaplasmas (≥ 10 CFU/ml) was observed significantly more frequently ( = 0.003). Determining the number of epithelial cells in Gram-stained slides may be the prognostic indicator of ureaplasma infection. Testing for genital ureaplasma infection should be considered, especially in women of childbearing age (18-40 years), even if the Nugent test value is normal and pH ≤ 4.6.
生殖道脲原体感染与许多并发症相关，范围从炎症到不孕再到妊娠问题。在脲原体感染过程中，人乳头瘤病毒感染的风险增加。脲原体感染的诊断测试并不总是进行，尤其是在阴道分泌物 Nugent 检测结果正常的女性中。本研究试图检查是否可以找到一个预测指标，该指标可以提示在阴道分泌物初始检查阶段脲原体（≥10CFU/ml）的丰度较高。这种预测因素可以使女性有资格进行进一步的检测，以检测这些非典型细菌的感染。对 627 名 Nugent 评分为 0-3 的白人女性进行了检测，包括 322 名脲原体丰度较高（≥10CFU/ml）的患者和 305 名这些细菌检测为阴性的患者。与阴道拭子标本中上皮细胞数量少或无的女性相比，脲原体感染在这些女性中检测到具有统计学意义（上皮细胞数量少或无）（<0.001）。与上皮细胞数量高的女性相比，上皮细胞数量少或无的女性脲原体高密度的风险高 38.7%。在 18-40 岁的上皮细胞数量少或无的患者中，观察到脲原体高密度（≥10CFU/ml）的频率显著更高（=0.003）。在革兰氏染色载玻片上确定上皮细胞数量可能是脲原体感染的预测指标。应考虑对生殖道脲原体感染进行检测，尤其是在育龄期（18-40 岁）的女性，即使 Nugent 检测值正常且 pH≤4.6。
