Gastroenterology Department, "Iuliu Haţieganu" University of Medicine and Pharmacy, Street Emil Isac No. 13, 400023 Cluj-Napoca, Romania.
Gastroenterology Department, Regional Institute of Gastroenterology and Hepatology "Prof. Dr. O. Fodor", Street Croitorilor No. 19-21, 400162 Cluj-Napoca, Romania.
Int J Mol Sci. 2022 Mar 28;23(7):3693. doi: 10.3390/ijms23073693.
Wound healing is a complex process that is mediated and influenced by several cytokines, chemokines, and growth factors. Interleukin-22 (IL-22) is a cytokine that plays a critical role in tissue regeneration. Our study is a systematic review that addressed the implications of IL-22 in the healing of wounds caused by external factors. Thirteen studies were included in our review, most of them being experimental studies. Three clinical studies underlined the potential role of IL-22 in day-to-day clinical practice. IL-22 plays a central role in wound healing, stimulating the proliferation, migration, and differentiation of the cells involved in tissue repair. However, overexpression of IL-22 can cause negative effects, such as keloid scars or peritoneal adhesions. The results of the presented studies are promising, but further research that validates the roles of IL-22 in clinical practice and analyzes its potential implication in surgical healing is welcomed.
伤口愈合是一个复杂的过程，受到多种细胞因子、趋化因子和生长因子的调节和影响。白细胞介素 22（IL-22）是一种在组织再生中起关键作用的细胞因子。我们的研究是一项系统评价，旨在探讨 IL-22 在外因性伤口愈合中的意义。我们的综述纳入了 13 项研究，其中大多数为实验研究。三项临床研究强调了 IL-22 在日常临床实践中的潜在作用。IL-22 在伤口愈合中起核心作用，刺激参与组织修复的细胞的增殖、迁移和分化。然而，IL-22 的过度表达可能会导致负面效应，如瘢痕疙瘩或腹膜粘连。目前研究结果很有前景，但需要进一步的研究来验证 IL-22 在临床实践中的作用，并分析其在手术愈合中的潜在意义。
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