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每日两次服用枸橼酸铋钾治疗十二指肠溃疡。

Twice daily tripotassium dicitrato bismuthate in the treatment of duodenal ulceration.

作者信息

Hollanders D

出版信息

Postgrad Med J. 1986 Jan;62(723):19-21. doi: 10.1136/pgmj.62.723.19.

DOI:10.1136/pgmj.62.723.19
PMID:3540918
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2418563/
Abstract

Fifty three patients with endoscopically proven duodenal ulceration have cooperated in a clinical trial to compare the ulcer healing effect of tripotassium dicitrato bismuthate (TDB) at standard dosage administered either twice or four times daily. No statistically significant difference has been found to exist between ulcer healing in the two groups at 4 weeks (72% and 67%, P = 0.944) or at 8 weeks (92% and 81%, P = 0.504) and it is concluded that twice daily TDB maintains the effectiveness of the drug and has advantages for patient compliance.

摘要

五十三例经内镜证实为十二指肠溃疡的患者参与了一项临床试验,以比较每日服用两次或四次标准剂量的枸橼酸铋钾(TDB)的溃疡愈合效果。在4周时(72%和67%,P = 0.944)或8周时(92%和81%,P = 0.504),两组的溃疡愈合情况均未发现统计学上的显著差异,得出的结论是,每日两次服用TDB可维持药物疗效,且对患者的依从性有好处。

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引用本文的文献

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2
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Gut. 1990 Sep;31(9):999-1002. doi: 10.1136/gut.31.9.999.

本文引用的文献

1
Selective coating of gastric ulcer by tripotassium dicitrato bismuthate in the rat.大鼠中用枸橼酸铋钾对胃溃疡进行选择性包被。
Gastroenterology. 1982 May;82(5 Pt 1):864-70.
2
Tri-potassium di citrato bismuthate chewing tablets and cimetidine tablets in the treatment of duodenal ulcers. A double-blind double-dummy comparative study.枸橼酸铋钾咀嚼片与西咪替丁片治疗十二指肠溃疡的双盲双模拟对照研究。
S Afr Med J. 1981 Sep 12;60(11):420-3.
3
Randomised open controlled trial of colloidal bismuth subcitrate tablets and cimetidine in the treatment of duodenal ulcer.枸橼酸铋钾片与西咪替丁治疗十二指肠溃疡的随机开放对照试验
Gut. 1980 Apr;21(4):329-33. doi: 10.1136/gut.21.4.329.
4
Comparison of cimetidine and tripotassium dicitrato bismuthate in healing and relapse of duodenal ulcers.西咪替丁与枸橼酸铋钾治疗十二指肠溃疡愈合及复发情况的比较
Digestion. 1983;28(2):96-101. doi: 10.1159/000198970.
5
Difference in relapse rates of duodenal ulcer after healing with cimetidine or tripotassium dicitrato bismuthate.西咪替丁或枸橼酸铋钾治疗十二指肠溃疡愈合后的复发率差异。
Lancet. 1981 Jan 3;1(8210):7-10. doi: 10.1016/s0140-6736(81)90114-8.
6
[Bismuth treatment and blood bismuth levels].[铋治疗与血铋水平]
Sem Hop. 1977 Sep;53(31-32):1663-9.