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在活细胞中研究合金化的 CdZnSeS/ZnS 量子点及其与 SPIONs 的纳米复合材料的时间和光谱分辨光致发光。

Time- and Spectrally-Resolved Photoluminescence Study of Alloyed CdZnSeS/ZnS Quantum Dots and Their Nanocomposites with SPIONs in Living Cells.

机构信息

Faculty of Photonics, School of Physics and Engineering, ITMO University, 197101 Saint Petersburg, Russia.

Institute of Cytology, Russian Academy of Science, 194064 Saint Petersburg, Russia.

出版信息

Int J Mol Sci. 2022 Apr 6;23(7):4061. doi: 10.3390/ijms23074061.

DOI:10.3390/ijms23074061
PMID:35409422
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8999546/
Abstract

Magnetic-luminescent composites based on semiconductor quantum dots (QDs) and superparamagnetic iron oxide nanoparticles (SPIONs) can serve as a platform combining visualization and therapy. Here, we report the construction of QD-SPION nanocomposites based on synthesized SPIONs and alloyed QDs (CdxZn1-xSeyS1-y)/ZnS solubilized with L-cysteine molecules. The study of the spectral-luminescence characteristics, the kinetics of luminescence decay show the composite's stability in a solution. After incubation with HeLa cells, QDs, SPIONs, and their composites form clusters on the cell surface and associate with endosomes inside the cells. Component-wise analysis of the photoluminescence decay of cell-associated QDs/SPIONs provides information about their localization and aggregate status.

摘要

基于半导体量子点 (QD) 和超顺磁性氧化铁纳米粒子 (SPION) 的磁致发光复合材料可用作结合可视化和治疗的平台。在此，我们报告了基于合成的 SPION 和用 L-半胱氨酸分子溶解的合金量子点 (CdxZn1-xSeyS1-y)/ZnS 构建的 QD-SPION 纳米复合材料。对光谱发光特性和发光衰减动力学的研究表明，该复合材料在溶液中具有稳定性。与 HeLa 细胞孵育后，QD、SPION 及其复合材料在细胞表面形成聚集体，并与细胞内的内体结合。与细胞相关的 QD/SPION 光致发光衰减的组分分析提供了有关其定位和聚集状态的信息。

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