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集成人工智能方法的用于癌症诊断和治疗的先进多功能磁性纳米结构综述

A Review of Advanced Multifunctional Magnetic Nanostructures for Cancer Diagnosis and Therapy Integrated into an Artificial Intelligence Approach.

作者信息

Govindan Bharath, Sabri Muhammad Ashraf, Hai Abdul, Banat Fawzi, Haija Mohammad Abu

机构信息

Department of Chemical Engineering, Khalifa University of Science and Technology, Abu Dhabi P.O. Box 127788, United Arab Emirates.

Department of Chemistry, Khalifa University of Science and Technology, Abu Dhabi P.O. Box 127788, United Arab Emirates.

出版信息

Pharmaceutics. 2023 Mar 7;15(3):868. doi: 10.3390/pharmaceutics15030868.

DOI:10.3390/pharmaceutics15030868
PMID:36986729
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10058002/
Abstract

The new era of nanomedicine offers significant opportunities for cancer diagnostics and treatment. Magnetic nanoplatforms could be highly effective tools for cancer diagnosis and treatment in the future. Due to their tunable morphologies and superior properties, multifunctional magnetic nanomaterials and their hybrid nanostructures can be designed as specific carriers of drugs, imaging agents, and magnetic theranostics. Multifunctional magnetic nanostructures are promising theranostic agents due to their ability to diagnose and combine therapies. This review provides a comprehensive overview of the development of advanced multifunctional magnetic nanostructures combining magnetic and optical properties, providing photoresponsive magnetic platforms for promising medical applications. Moreover, this review discusses various innovative developments using multifunctional magnetic nanostructures, including drug delivery, cancer treatment, tumor-specific ligands that deliver chemotherapeutics or hormonal agents, magnetic resonance imaging, and tissue engineering. Additionally, artificial intelligence (AI) can be used to optimize material properties in cancer diagnosis and treatment, based on predicted interactions with drugs, cell membranes, vasculature, biological fluid, and the immune system to enhance the effectiveness of therapeutic agents. Furthermore, this review provides an overview of AI approaches used to assess the practical utility of multifunctional magnetic nanostructures for cancer diagnosis and treatment. Finally, the review presents the current knowledge and perspectives on hybrid magnetic systems as cancer treatment tools with AI models.

摘要

纳米医学的新时代为癌症诊断和治疗提供了重大机遇。磁性纳米平台未来可能成为癌症诊断和治疗的高效工具。由于其可调节的形态和优异的性能，多功能磁性纳米材料及其混合纳米结构可被设计为药物、成像剂和磁诊疗剂的特定载体。多功能磁性纳米结构因其具备诊断和联合治疗的能力，是很有前景的诊疗剂。本综述全面概述了结合磁性和光学性质的先进多功能磁性纳米结构的发展，为有前景的医学应用提供光响应磁性平台。此外，本综述讨论了使用多功能磁性纳米结构的各种创新进展，包括药物递送、癌症治疗、递送化疗药物或激素制剂的肿瘤特异性配体、磁共振成像和组织工程。此外，人工智能（AI）可用于基于与药物、细胞膜、脉管系统、生物流体和免疫系统的预测相互作用来优化癌症诊断和治疗中的材料特性，以提高治疗剂的有效性。此外，本综述概述了用于评估多功能磁性纳米结构在癌症诊断和治疗中的实际效用的人工智能方法。最后，本综述介绍了关于作为癌症治疗工具的混合磁性系统与人工智能模型的当前知识和观点。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0fe/10058002/cfe62af5fd0e/pharmaceutics-15-00868-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0fe/10058002/39d02884f62b/pharmaceutics-15-00868-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0fe/10058002/5e326fbd2ef2/pharmaceutics-15-00868-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0fe/10058002/b7825d3dac61/pharmaceutics-15-00868-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0fe/10058002/0ce5b954089b/pharmaceutics-15-00868-g011.jpg
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