Division of General Practice, Department of Medical Education, Changhua Christian Hospital, Changhua 500, Taiwan.
Oral Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan.
Int J Environ Res Public Health. 2022 Mar 27;19(7):3974. doi: 10.3390/ijerph19073974.
Lysine methyltransferase 2C (KMT2C) is a tumor-suppressor gene in several myeloid cells and epithelia and is linked with blood and solid tumor cancers. KMT2C single-nucleotide polymorphisms (SNPs) are also connected with several cancer types. Our study aimed to explore the potential genetic polymorphisms of KMT2C in oral cancer. Five KMT2C SNPs, including rs201834857, rs4725443, rs6464221, rs74483926, and rs6943984, were evaluated in 284 cancer-free controls and 284 oral squamous cell carcinoma (OSCC) cases. We found that individuals with the TC genotype or TC + CC genotype of rs4725443 had a higher risk of oral cancer incidence than those with the TT genotype. Further analysis of KMT2C SNP rs4725443 revealed that the TC + CC genotype of rs4725443 was associated with a significantly advanced tumor stage in the non-alcohol-drinking population. Moreover, the TC + CC genotype of rs4725443 was connected with poor cell differentiation in the alcohol-drinking population. Through analyzing a dataset from The Cancer Genome Atlas (TCGA), we found that reduced KMT2C levels were associated with advanced tumor stage, lymph node invasion, and poor cell differentiation in head and neck squamous cell carcinomas. Our data suggest that KMT2C SNP rs4725443 is a potential genetic marker for oral cancer patients in both non-alcohol-drinking and alcohol-drinking populations.
赖氨酸甲基转移酶 2C（KMT2C）是几种骨髓细胞和上皮细胞中的肿瘤抑制基因，与血液和实体肿瘤癌症有关。KMT2C 单核苷酸多态性（SNP）也与几种癌症类型有关。我们的研究旨在探讨口腔癌中 KMT2C 的潜在遗传多态性。评估了 284 名无癌症对照和 284 名口腔鳞状细胞癌（OSCC）病例中的 5 个 KMT2C SNP，包括 rs201834857、rs4725443、rs6464221、rs74483926 和 rs6943984。我们发现，rs4725443 的 TC 基因型或 TC + CC 基因型个体患口腔癌的风险高于 TT 基因型个体。对 KMT2C SNP rs4725443 的进一步分析表明，非饮酒人群中 rs4725443 的 TC + CC 基因型与肿瘤分期显著进展有关。此外，rs4725443 的 TC + CC 基因型与饮酒人群中细胞分化不良有关。通过分析来自癌症基因组图谱（TCGA）的数据集，我们发现 KMT2C 水平降低与头颈部鳞状细胞癌的肿瘤晚期、淋巴结浸润和细胞分化不良有关。我们的数据表明，KMT2C SNP rs4725443 是非饮酒和饮酒人群中口腔癌患者的潜在遗传标志物。
