Department of Family Medicine, Uijeongbu Eulji Medical Center, Eulji Unversity, Daejeon, Gyeonggi-do, Republic of Korea.
Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
BMC Geriatr. 2022 Apr 11;22(1):319. doi: 10.1186/s12877-022-03019-1.
Adults with low muscle mass have a poor prognosis. Studies that examined the association between total protein intake and low muscle mass among adults are limited. Thus, we investigated the association between total protein intake and low muscle mass among Korean adults aged ≥19 years.
We included 15,995 adults (6528 male and 9467 female) aged ≥19 years from the Korea National Health and Nutrition Examination Surveys (2008-2011). We divided the participants into groups according to protein intake quartile: Q1, Q2, Q3 and Q4 groups. The odds ratios (ORs) and 95% confidence intervals (CIs) of low muscle mass according to protein intake were analysed via multivariable logistic regression analysis. Stratified analyses according to sex, age and comorbidities were also performed.
Of the participants, 3.8% had weight-adjusted low muscle mass. The prevalence rates of low muscle mass were 1.5, 3.0, 3.9 and 7.2% in the Q4, Q3, Q2 and Q1 groups, respectively (p < 0.001). Compared with the Q4 group, the Q1 group had the highest ORs for low muscle mass, followed by the Q2 and Q3 groups (Model 5; OR, 95% CI: 2.03, 1.36-3.02 for Q3; 2.44, 1.64-3.61 for Q2; and 4.32, 2.89-6.45 for Q4) after adjusting for confounding variables (p for trend < 0.001). The associations between protein intake and low muscle mass were stronger in younger individuals, men, individuals without hypertension, those with diabetes mellitus and those without dyslipidemia.
The prevalence of low muscle mass in Korean adults significantly increased with lower protein intake. Nutrition education for proper protein intake is also important for adults.
Retrospectively registered.
肌肉量低的成年人预后较差。研究表明，总蛋白摄入量与成年人肌肉量低之间存在关联，但此类研究有限。因此，我们调查了韩国≥19 岁成年人的总蛋白摄入量与低肌肉量之间的关系。
我们纳入了韩国国家健康与营养调查（2008-2011 年）中≥19 岁的 15995 名成年人（男 6528 名，女 9467 名）。我们根据蛋白质摄入量四分位区间将参与者分为 4 组：Q1、Q2、Q3 和 Q4 组。通过多变量逻辑回归分析，分析了总蛋白摄入量与低肌肉量的比值比（OR）和 95%置信区间（CI）。还根据性别、年龄和合并症进行了分层分析。
在参与者中，有 3.8%的人体重调整后的肌肉量低。肌肉量低的患病率在 Q4、Q3、Q2 和 Q1 组分别为 1.5%、3.0%、3.9%和 7.2%（p<0.001）。与 Q4 组相比，Q1 组的低肌肉量 OR 最高，其次是 Q2 和 Q3 组（模型 5；OR，95%CI：Q3 为 2.03，1.36-3.02；Q2 为 2.44，1.64-3.61；Q4 为 4.32，2.89-6.45），调整混杂因素后（p<0.001）。在年轻人群、男性、无高血压人群、有糖尿病人群和无血脂异常人群中，蛋白质摄入量与低肌肉量之间的关联更强。
韩国成年人低肌肉量的患病率随着蛋白质摄入量的降低而显著增加。适当蛋白质摄入的营养教育对成年人也很重要。
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