Emslie K R, Nade S
Rev Infect Dis. 1986 Nov-Dec;8(6):841-9. doi: 10.1093/clinids/8.6.841.
Antibiotic therapy and surgical drainage of the bone are the most commonly accepted forms of therapy for acute hematogenous osteomyelitis; the efficacy of these two treatment modalities, however, has not been fully established. Treatment regimens remain empiric and open to much controversy. Many contentious issues concerning the management of this disease have arisen because the natural history of the untreated condition has not been properly understood, because therapeutic regimens alternative to those empirically initiated and perpetuated have not been adequately tested, and because most follow-up studies have dealt with small numbers of patients over relatively short periods. A highly reproducible animal model of acute hematogenous osteomyelitis was developed and utilized in a reexamination of issues regarding the natural history and pathology of the disease and the influence of appropriate treatment.
抗生素治疗和骨外科引流是急性血源性骨髓炎最常用的治疗方法；然而，这两种治疗方式的疗效尚未完全确立。治疗方案仍然是经验性的，且存在诸多争议。由于未正确理解未经治疗疾病的自然病程，由于未充分测试经验性启动和持续使用的治疗方案之外的其他治疗方案，还由于大多数随访研究涉及的患者数量较少且随访时间相对较短，因此出现了许多关于该疾病管理的有争议问题。我们开发了一种高度可重复的急性血源性骨髓炎动物模型，并将其用于重新审视有关该疾病自然病程和病理以及适当治疗影响的问题。
