Emslie K R, Nade S
Pathology. 1986 Apr;18(2):227-33. doi: 10.3109/00313028609059464.
Surgical drilling and curettage of metaphyseal medullary bone were performed in chickens 4, 8 and 15 d after bacterial inoculation with Staphylococcus aureus producing osteomyelitis. Intramedullary drilling and curettage resulted in extensive vascular damage and necrosis of medullary bone but failed to remove all viable bacteria. An effective continuing drainage channel for the pus was not established due to the formation of blood clot within the drill hole. Surgery performed before the formation of a sequestrum resulted in further spread of bacteria within the medullary cavity and the formation of a larger sequestrum than that commonly observed in the bones of infected, untreated chickens. Surgery performed after the formation of a sequestrum destroyed the abscess wall thus disrupting a natural defence mechanism of the host. Whilst a direct comparison of surgical drilling in human osteomyelitis and in this avian model cannot be made, the results suggest that production of an artificial drill hole across the cortex and curettage of the bone in human osteomyelitis would be destructive and may not be warranted.
在接种产生骨髓炎的金黄色葡萄球菌后的第4、8和15天，对鸡进行干骺端髓质骨的手术钻孔和刮除术。髓内钻孔和刮除导致广泛的血管损伤和髓质骨坏死，但未能清除所有存活细菌。由于钻孔内形成血凝块，未建立有效的脓液持续引流通道。在死骨形成之前进行手术导致细菌在髓腔内进一步扩散，并形成比感染但未治疗的鸡的骨骼中通常观察到的更大的死骨。在死骨形成之后进行手术破坏了脓肿壁，从而破坏了宿主的天然防御机制。虽然无法对人类骨髓炎和该禽类模型中的手术钻孔进行直接比较，但结果表明，在人类骨髓炎中穿过皮质制作人工钻孔并刮除骨组织具有破坏性，可能并不合理。
