Emslie K R, Nade S
Pathology. 1984 Oct;16(4):441-6. doi: 10.3109/00313028409084737.
A reproducible avian model of acute hematogenous staphylococcal osteomyelitis was used to investigate various aspects of antibiotic therapy using a single antibiotic, cloxacillin. The effects of both delaying antibiotic administration and increasing the frequency of antibiotic administration on the outcome of the disease were evaluated. Following bacterial inoculation, a delay in commencing therapy for 4 d in comparison to 1 d significantly reduced the likelihood of a favourable outcome. An increase in the frequency of antibiotic administration from once to 4 times daily resulted in significant improvement in the recovery rate of chickens. Whilst repeated antibiotic administration controlled the systemic effects of the disease and improved the clinical status of chickens, the local bone lesion was not always sterilized. The role of antibiotic therapy in acute hematogenous osteomyelitis is discussed in relation to these findings.
采用一种可重复的急性血源性金黄色葡萄球菌骨髓炎禽类模型，使用单一抗生素氯唑西林来研究抗生素治疗的各个方面。评估了延迟抗生素给药和增加抗生素给药频率对疾病转归的影响。细菌接种后，与1天开始治疗相比，延迟4天开始治疗显著降低了获得良好转归的可能性。抗生素给药频率从每天1次增加到4次，使鸡的恢复率显著提高。虽然重复使用抗生素可控制疾病的全身影响并改善鸡的临床状况，但局部骨病变并不总是能被清除。结合这些发现讨论了抗生素治疗在急性血源性骨髓炎中的作用。
