Tibayrenc M, Hoffmann A, Poch O, Echalar L, Le Pont F, Lemesre J L, Desjeux P, Ayala F J
Trans R Soc Trop Med Hyg. 1986;80(3):442-7. doi: 10.1016/0035-9203(86)90338-x.
We have collected in Bolivia 212 stocks of Trypanosoma cruzi from domestic transmission cycles and have assayed for nine enzyme systems (11 gene loci). Only a few different isozyme profiles exist, without recombination between them, a situation also encountered in previous Bolivian samples. The 212 stocks, combined with 207 stocks previously studied, have been analysed to uncover any spatial patterns. The frequency of heterozygous strains (2 and 2a) decreases westwards and with increasing altitude. Given that longitude and altitude are correlated with each other, it is not possible to decide which of these two geographic variables is the relevant one, or if both are. These associations might be due to climatic factors. Studies by other authors have shown, however, that heterozygous strains are rare or absent in the Amazon Basin, which is at low altitude.
我们在玻利维亚收集了212株来自家庭传播周期的克氏锥虫，并对9种酶系统（11个基因位点）进行了检测。仅存在少数几种不同的同工酶谱，且它们之间没有重组现象，这种情况在之前的玻利维亚样本中也有出现。将这212株样本与之前研究的207株样本相结合，进行分析以发现任何空间模式。杂合菌株（2型和2a型）的频率向西降低，且随着海拔升高而降低。鉴于经度和海拔相互关联，无法确定这两个地理变量中哪一个是相关的，或者是否两者都相关。这些关联可能是由于气候因素。然而，其他作者的研究表明，在低海拔的亚马逊盆地，杂合菌株很少见或不存在。
