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[克氏锥虫同工酶株的分类学和医学地位。对各种同工酶的系统发育和免疫学价值的思考]

[Taxonomic and medical status of isoenzyme strains of Trypanosoma cruzi. Considerations of the systematic and immunologic values of various isoenzymes].

作者信息

Tibayrenc M, Echalar L, Brénière F, Lemesre J L, Barnabé C, Desjeux P

出版信息

C R Seances Acad Sci III. 1983;296(15):721-6.

PMID:6412985
Abstract

The genetic distance calculations for 45 Bolivian stocks of Trypanosoma cruzi show the lack of continuum among them and allow to distinguish two main groups, which origin is perhaps a passed speciation. The presence of some heterogeneity within each group leads us to propose a temporary terminology: each isozymic variant is called "zymostrain" without prejudging its medical or taxonomic importance. The relationships between biochemical Taxonomy and medical data are discussed. The taxonomic value of the different isoenzymes is examined. The possible immunogenic properties of some of them (particularly Glutamate deshydrogenase) is discussed.

摘要

对45个玻利维亚克氏锥虫株系进行的遗传距离计算表明,它们之间缺乏连续性,可区分出两个主要群体,其起源可能是一次过去的物种形成。每个群体中存在的一些异质性使我们提出一个临时术语:每个同工酶变体称为“酶株”,而不预先判断其医学或分类学重要性。讨论了生化分类学与医学数据之间的关系。研究了不同同工酶的分类学价值。讨论了其中一些同工酶(特别是谷氨酸脱氢酶)可能的免疫原性。

相似文献

1
[Taxonomic and medical status of isoenzyme strains of Trypanosoma cruzi. Considerations of the systematic and immunologic values of various isoenzymes].[克氏锥虫同工酶株的分类学和医学地位。对各种同工酶的系统发育和免疫学价值的思考]
C R Seances Acad Sci III. 1983;296(15):721-6.
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The microdistribution of isoenzymic strains of Trypanosoma cruzi in southern Bolivia; new isoenzyme profiles and further arguments against Mendelian sexuality.克氏锥虫同工酶菌株在玻利维亚南部的微观分布;新的同工酶谱及对孟德尔式有性生殖的进一步反驳论据
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Trypanosoma cruzi: impact of clonal evolution of the parasite on its biological and medical properties.克氏锥虫:寄生虫克隆进化对其生物学和医学特性的影响。
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引用本文的文献

1
Natural populations of Trypanosoma cruzi, the agent of Chagas disease, have a complex multiclonal structure.恰加斯病的病原体克氏锥虫的自然种群具有复杂的多克隆结构。
Proc Natl Acad Sci U S A. 1986 Jan;83(1):115-9. doi: 10.1073/pnas.83.1.115.