Ferrante Enrico, Trimboli Michele, Erminio Cristina, Martino Iolanda, Tiraboschi Pietro
Department of Neurology, Alto Vicentino Hospital - AULSS 7 Pedemontana, Santorso (IT), Italy; Department of Neurology, AOR San Carlo, Potenza, Italy; Department of Neuroradiology, Niguarda Ca Granda Hospital-Milan (IT), Italy.
Department of Neurology, AOR San Carlo, Potenza, Italy; Institute of Neurology, Department of Medical and Surgical Sciences, Magna Græcia University, Catanzaro (IT), Italy.
Clin Neurol Neurosurg. 2022 May;216:107239. doi: 10.1016/j.clineuro.2022.107239. Epub 2022 Apr 6.
Acute confusional state associated with migraine in adults is an infrequent entity. Around 30-60% of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) patients get affected by migraine attacks-the majority with aura-often as the first symptom of the disease. Acute confusional state during migraine has been rarely described in CADASIL patients and a complete neuropsychological assessment during the acute phase has never been conducted so far.
We here describe the clinical and neuropsychological features of two distinct episodes of ACM in a 54-year-old female with CADASIL. EEG recording during acute confusional migraine and after attack resolution and neuroimaging has been reported.
This paper also reports a literature review on the topic of ACM in CADASIL highlighting a lack of adequate knowledge about this entity among clinicians and prompting further larger studies to explore its incidence and characteristics.
