Strickland G T
Tropenmed Parasitol. 1978 Jun;29(2):198-203.
To test for the presence of a lymphocyte mitogenic factor in malaria, sera were obtained from 10 patients with malaria (9 with falciparum and one with vivax), and 10 noninfected controls. The sera from the malarial patients caused an increased blastogenesis in mouse splenic lymphocyte cultures and inhibited hemagglutination between lipid-A-coated erythrocytes and lipid-A antibodies. None of the sera were positive using the limulus amebocyte lysate test. These results could be interpreted to demonstrate that patients with falciparum malaria have a circulating mitogen which cross-reacts with endotoxin. However, alternate explanations must be considered, including an hypothesis that antiglobulins and/or immune complexes in the sera of malarious patients both caused the blastogenesis of mouse spleen cells and inhibited hemagglutination to lipid-A antibodies.
为检测疟疾中是否存在淋巴细胞促有丝分裂因子，从10例疟疾患者（9例恶性疟和1例间日疟）及10名未感染对照者获取血清。疟疾患者的血清使小鼠脾淋巴细胞培养中的细胞增殖增加，并抑制脂质A包被的红细胞与脂质A抗体之间的血凝反应。使用鲎试剂检测时，所有血清均为阴性。这些结果可解释为表明恶性疟患者有一种与内毒素交叉反应的循环促有丝分裂原。然而，必须考虑其他解释，包括一种假说，即疟疾患者血清中的抗球蛋白和/或免疫复合物既导致小鼠脾细胞的细胞增殖，又抑制对脂质A抗体的血凝反应。
