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聚乙二醇二甲醚介导的分子氧将芳族烯烃氧化裂解为羰基化合物

Poly(ethylene glycol) dimethyl ether mediated oxidative scission of aromatic olefins to carbonyl compounds by molecular oxygen.

作者信息

Yu Tao, Guo Mingqing, Wen Simiaomiao, Zhao Rongrong, Wang Jinlong, Sun Yanli, Liu Qixing, Zhou Haifeng

机构信息

Research Center of Green Pharmaceutical Technology and Process, Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University Yichang 443002 China

出版信息

RSC Adv. 2021 Apr 14;11(23):13848-13852. doi: 10.1039/d1ra02007b. eCollection 2021 Apr 13.

DOI:10.1039/d1ra02007b
PMID:35423908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8697527/
Abstract

A simple, and practical oxidative scission of aromatic olefins to carbonyl compounds using O as the sole oxidant with poly(ethylene glycol) dimethyl ether as a benign solvent has been developed. A wide range of monosubstituted, -disubstituted, 1,2-disubstituted, trisubstituted and tetrasubstituted aromatic olefins was successfully converted into the corresponding aldehydes and ketones in excellent yields even with gram-scale reaction. Some control experiments were also conducted to support a possible reaction pathway.

摘要

已开发出一种简单且实用的方法，以氧气作为唯一氧化剂，聚乙二醇二甲醚作为良性溶剂，将芳香烯烃氧化裂解为羰基化合物。即使进行克级规模的反应，各种单取代、双取代、1,2 - 二取代、三取代和四取代的芳香烯烃也能成功转化为相应的醛和酮，产率优异。还进行了一些对照实验以支持可能的反应途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/8697527/5af2f8709c24/d1ra02007b-s6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/8697527/54f2cc2db3e7/d1ra02007b-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/8697527/9084702dd741/d1ra02007b-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/8697527/41dd71978dcd/d1ra02007b-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/8697527/47203b2685e2/d1ra02007b-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/8697527/670ecb18792f/d1ra02007b-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/8697527/5af2f8709c24/d1ra02007b-s6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/8697527/54f2cc2db3e7/d1ra02007b-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/8697527/9084702dd741/d1ra02007b-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/8697527/41dd71978dcd/d1ra02007b-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/8697527/47203b2685e2/d1ra02007b-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/8697527/670ecb18792f/d1ra02007b-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2104/8697527/5af2f8709c24/d1ra02007b-s6.jpg

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