Wang Zhen-Zhen, Jia Yuan, Wang Guoqiang, He Hongjuan, Cao Lihua, Shi Yanmei, Miao Mingsan, Li Xiu-Min
Academy of Chinese Medical Science, Henan University of Chinese Medicine Zhengzhou China
Department of Pathology, Microbiology & Immunology, New York Medical College Valhalla NY USA
RSC Adv. 2022 Mar 21;12(14):8737-8742. doi: 10.1039/d1ra07553e. eCollection 2022 Mar 15.
Baicalin has been demonstrated to have multiple pharmacological activities but low solubility. Various baicalin hydrogels have been used to improve its solubility and break its limitation in clinical applications. However, traditional baicalin hydrogels contain numerous ingredients and usually show low baicalin loading capacity. Herein, we discovered a dynamic covalent hydrogel only consisting of baicalin and inorganic borate, in which baicalin is considered as the carrier and drug without other ingredients. The dynamic boronate bonds endow the hydrogel with excellent degradability and multi-stimuli-responsiveness. Moreover, the hydrogel displayed remarkable thixotropy, moldability, and self-healing properties. And the biocompatible baicalin hydrogel exhibited significant antibacterial activities, and can be considered as a potential drug delivery system for biomedical applications.
黄芩苷已被证明具有多种药理活性，但溶解度较低。各种黄芩苷水凝胶已被用于提高其溶解度并突破其在临床应用中的限制。然而，传统的黄芩苷水凝胶含有多种成分，通常显示出较低的黄芩苷负载能力。在此，我们发现了一种仅由黄芩苷和无机硼酸盐组成的动态共价水凝胶，其中黄芩苷被视为载体和药物，不含其他成分。动态硼酸酯键赋予水凝胶优异的降解性和多刺激响应性。此外，该水凝胶表现出显著的触变性、可模塑性和自愈性能。并且这种具有生物相容性的黄芩苷水凝胶表现出显著的抗菌活性，可被视为一种潜在的生物医学应用药物递送系统。
