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生物点击化学：生物催化与点击化学之间的桥梁。

Bio-click chemistry: a bridge between biocatalysis and click chemistry.

作者信息

Rodríguez Diego F, Moglie Yanina, Ramírez-Sarmiento César A, Singh Sachin Kumar, Dua Kamal, Zacconi Flavia C

机构信息

Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile Chile

Departamento de Química, INQUISUR, Universidad Nacional del Sur (UNS)-CONICET Argentina.

出版信息

RSC Adv. 2022 Jan 12;12(4):1932-1949. doi: 10.1039/d1ra08053a.

DOI:10.1039/d1ra08053a
PMID:35425264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8979012/
Abstract

The fields of click chemistry and biocatalysis have rapidly grown over the last two decades. The development of robust and active biocatalysts and the widespread use of straightforward click reactions led to significant interactions between these two fields. Therefore the name bio-click chemistry seems to be an accurate definition of chemoenzymatic reactions cooperating with click transformations. Bio-click chemistry can be understood as the approach towards molecules of high-value using a green and sustainable approach by exploiting the potential of biocatalytic enzyme activity combined with the reliable nature of click reactions. This review summarizes the principal bio-click chemistry reactions reported over the last two decades, with a special emphasis on small molecules. Contributions to the field of bio-click chemistry are manifold, but the synthesis of chiral molecules with applications in medicinal chemistry and sustainable syntheses will be especially highlighted.

摘要

在过去二十年中，点击化学和生物催化领域迅速发展。强大且活性高的生物催化剂的开发以及直接点击反应的广泛应用，使得这两个领域之间产生了显著的相互作用。因此，“生物点击化学”这个名称似乎是对与点击转化协同作用的化学酶促反应的准确界定。生物点击化学可理解为一种利用生物催化酶活性的潜力并结合点击反应的可靠特性，以绿色且可持续的方式合成高价值分子的方法。本综述总结了过去二十年报道的主要生物点击化学反应，特别侧重于小分子。生物点击化学领域的贡献是多方面的，但将特别突出在药物化学和可持续合成中应用的手性分子的合成。

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