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制药研发中生物催化的不断演变的本质。

The Evolving Nature of Biocatalysis in Pharmaceutical Research and Development.

作者信息

France Scott P, Lewis Russell D, Martinez Carlos A

机构信息

Pfizer Worldwide Research and Development, 445 Eastern Point Road, Groton, Connecticut 06340, United States.

出版信息

JACS Au. 2023 Feb 27;3(3):715-735. doi: 10.1021/jacsau.2c00712. eCollection 2023 Mar 27.

DOI:10.1021/jacsau.2c00712
PMID:37006753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10052283/
Abstract

Biocatalysis is a highly valued enabling technology for pharmaceutical research and development as it can unlock synthetic routes to complex chiral motifs with unparalleled selectivity and efficiency. This perspective aims to review recent advances in the pharmaceutical implementation of biocatalysis across early and late-stage development with a focus on the implementation of processes for preparative-scale syntheses.

摘要

生物催化是制药研发中一项极具价值的使能技术，因为它能够以无与伦比的选择性和效率开辟通往复杂手性基序的合成路线。本文旨在综述生物催化在制药领域从早期到后期开发过程中的最新进展，重点关注制备规模合成工艺的实施情况。

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