Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
VIHTALI (Value in Health Technology and Academy for Leadership & Innovation), Spin-Off of Università Cattolica del Sacro Cuore, Rome, Italy.
Influenza Other Respir Viruses. 2022 Sep;16(5):820-831. doi: 10.1111/irv.12991. Epub 2022 Apr 15.
Pediatric influenza causes significant morbidity annually, resulting in an increased economic burden. Therefore, we aimed to summarize existing literature regarding the costs of pediatric influenza in Europe, paying particular attention to the direct and indirect costs considered in the economic evaluations. Knowing health and social costs of childhood influenza is essential to support value-based health decisions to implement effective immunization strategies.
We searched three databases for articles published to September 3, 2021. Eligible studies were those reporting the economic burden of influenza in the pediatric and youth population in European countries written in English language.
Overall, 2225 records were screened, and 9 articles were included. Costs estimates are different across countries and in the age groups considered. Direct costs per episode, whose major expense driver are hospitalizations and pediatric examinations, range from about €74 in Italy to €252 in Germany. Important variations are observed based on age, with the youngest group absorbing in some cases double the resources of the older ones such as (in Italy, in France and in Germany). Regarding indirect costs, workdays lost by parents resulted in higher costs for children <2 years and 2-5 years than those >5 years of age and their economic impact was variable reaching €251 per week in Germany.
Evidence obtained in our review strengthened the awareness about the economic impact, in terms of direct and indirect costs, of pediatric influenza requiring, as a priority action in Europe, the implementation of influenza vaccination policies in this target population.
儿童流感每年都会导致严重的发病，造成经济负担加重。因此，我们旨在总结欧洲关于儿童流感成本的现有文献，特别关注经济评估中考虑的直接和间接成本。了解儿童流感的健康和社会成本对于支持基于价值的卫生决策以实施有效的免疫接种策略至关重要。
我们在三个数据库中搜索了截至 2021 年 9 月 3 日发表的文章。符合条件的研究是报告了在欧洲国家的儿科和青少年人群中流感经济负担的英文文章。
共筛选了 2225 条记录，纳入了 9 篇文章。成本估计因国家和考虑的年龄组而异。每次发作的直接成本，其主要费用驱动因素是住院和儿科检查，从意大利的约 74 欧元到德国的 252 欧元不等。根据年龄观察到重要的差异，最年轻的群体在某些情况下吸收的资源是年龄较大群体的两倍，例如（在意大利、法国和德国）。关于间接成本，父母因失去工作日而导致 2 岁以下和 2-5 岁儿童的成本高于 5 岁以上儿童，其经济影响因国家而异，在德国每周可达 251 欧元。
我们的综述获得的证据增强了对儿童流感直接和间接成本经济影响的认识，这需要在欧洲将该目标人群的流感疫苗接种政策作为优先行动。
