Division of Medicine and Dentistry, Medical University of Warsaw, 02-091 Warsaw, Poland.
Department of Food Immunology and Microbiology, Polish Academy of Sciences, 10-748 Olsztyn, Poland.
Int J Mol Sci. 2024 Nov 5;25(22):11868. doi: 10.3390/ijms252211868.
Epidemiologically, one of the most important concerns associated with introducing spp. into the environment and food chain is the presence of asymptomatic carriers. The oncogenic and oncolytic activity of and their lipopolysaccharides (LPSs) is important and research on this topic is needed. Even a single asymptomatic dose of the Enteritidis LPS (a dose that has not caused any symptoms of illness) in in vivo studies induces the dysregulation of selected cells and bioactive substances of the nervous, immune, and endocrine systems. LPSs from different species, and even LPSs derived from different serotypes of one species, can define different biological activities. The activity of low doses of LPSs derived from three different serotypes (. Enteritidis, Typhimurium, and Minnesota) affects the neurochemistry of neurons differently in in vitro studies. Studies on lipopolysaccharides from different serotypes do not consider the diversity of their activity. The presence of an LPS from . Enteritidis in the body, even in amounts that do not induce any symptoms of illness, may lead to unknown long-term consequences associated with its action on the cells and biologically active substances of the human body. These conclusions should be important for both research strategies and the pharmaceutical industry &.
从流行病学的角度来看，将 spp. 引入环境和食物链中最令人关注的问题之一是无症状携带者的存在。 和它们的脂多糖 (LPS) 的致癌和溶瘤活性很重要，需要对此进行研究。即使在体内研究中单次摄入无症状剂量的 肠炎 LPS（未引起任何疾病症状的剂量），也会导致神经、免疫和内分泌系统的选定细胞和生物活性物质失调。来自不同物种的 LPS，甚至来自同一物种的不同血清型的 LPS，都可以定义不同的生物学活性。来自三种不同血清型（肠炎、鼠伤寒和明尼苏达）的低剂量 LPS 的活性在体外研究中对神经元的神经化学产生不同的影响。对不同血清型的脂多糖的研究没有考虑到它们活性的多样性。肠炎 LPS 的存在，即使在不引起任何疾病症状的量下，也可能导致与其对人体细胞和生物活性物质的作用相关的未知长期后果。这些结论对研究策略和制药行业都很重要。
