Madison Annelise A, Kiecolt-Glaser Janice K
Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, USA; Department of Psychology, The Ohio State University, USA.
Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, USA; Department of Psychiatry and Behavioral Health, The Ohio State University College of Medicine, USA.
Psychoneuroendocrinology. 2022 Jul;141:105763. doi: 10.1016/j.psyneuen.2022.105763. Epub 2022 Apr 9.
In both animals and humans, inflammatory stimuli - especially infections and endotoxin injections - cause "sickness behaviors," including lethargy, malaise, and low mood. An emerging line of research asserts that inflammation may provoke present-focused decision making and impulsivity. The current article assesses that claim in the context of the broader literature - including preclinical models and clinical interventions. This literature presents three challenges to purported inflammation-impulsivity link that have not been addressed to date: (1) the nebulous and imprecise definition of impulsivity; (2) reverse causality; and (3) a lack of causal evidence. These challenges point to ways in which future research designs can improve upon the extant literature to further explore the ostensible relationship between inflammation and impulsivity.
在动物和人类中，炎症刺激——尤其是感染和注射内毒素——会引发“疾病行为”，包括嗜睡、不适和情绪低落。一项新兴的研究表明，炎症可能会引发关注当下的决策和冲动行为。本文在更广泛的文献背景下评估了这一说法，包括临床前模型和临床干预。这些文献对炎症与冲动行为之间的所谓联系提出了三个迄今尚未解决的挑战：（1）冲动行为的定义模糊且不精确；（2）反向因果关系；（3）缺乏因果证据。这些挑战指出了未来研究设计可以在现有文献基础上进行改进的方向，以进一步探索炎症与冲动行为之间表面上的关系。
