人类疾病中的DNA分析。
DNA analysis in human disease.
作者信息
Wright A F
出版信息
J Clin Pathol. 1986 Dec;39(12):1281-95. doi: 10.1136/jcp.39.12.1281.
Abstract
The analysis of human DNA using recombinant DNA technology is fast becoming an integral part of the diagnosis, assessment, and prevention of inherited and somatic genetic disease. The rationale underlying these methods of analysis is discussed, and the nature and extent of mutational change in heritable disorders and neoplastic development is outlined.
摘要
利用重组DNA技术对人类DNA进行分析，正迅速成为遗传性和体细胞遗传病诊断、评估及预防不可或缺的一部分。本文讨论了这些分析方法背后的基本原理，并概述了遗传性疾病和肿瘤发生过程中突变变化的性质和程度。
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