c-bas/has人类原癌基因内的替代点突变导致转化特性的获得。
Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene.
作者信息
Yuasa Y, Srivastava S K, Dunn C Y, Rhim J S, Reddy E P, Aaronson S A
出版信息
Nature. 1983 Jun 30;303(5920):775-9. doi: 10.1038/303775a0.
DOI:10.1038/303775a0
PMID:6866079
Abstract
The transforming gene of a human lung carcinoma-derived cell line, Hs242, has been cloned in biologically active form, and identified as c-bas/has (otherwise known as c-Ha-ras). The genetic lesion responsible for the transforming activity of the Hs242 oncogene has been localized to a point mutation in the second exon which results in the substitution of leucine for glutamine as amino acid 61 of the predicted protein. No changes were observed in the first exon, the region of c-bas/has in which a point mutation is responsible for activation of the T24 and EJ bladder carcinoma oncogenes.
摘要
人肺癌衍生细胞系Hs242的转化基因已被克隆为具有生物活性的形式，并被鉴定为c-bas/has（也称为c-Ha-ras）。导致Hs242癌基因转化活性的遗传损伤已定位到第二个外显子中的一个点突变，该突变导致预测蛋白质的第61位氨基酸由谷氨酰胺替换为亮氨酸。在第一个外显子中未观察到变化，c-bas/has的该区域中的一个点突变导致T24和EJ膀胱癌癌基因的激活。
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