Rasoulianboroujeni Morteza, Yadegari Amir, Tajik Sanaz, Tayebi Lobat
Marquette University School of Dentistry, Milwaukee, WI, 53233, USA.
Mater Lett. 2022 Jul 1;318. doi: 10.1016/j.matlet.2022.132170. Epub 2022 Mar 28.
A modular design composed of 3D-printed polycaprolactone (PCL) as the load-bearing module, and dual porosity gelatin foam as the bio-reactive module, was developed and characterized in this study. Surface treatment of the PCL module through aminolysis-aldehyde process was found to yield a stronger interface bonding compared to NaOH hydrolysis, and therefore was used in the fabrication procedure. The modular scaffold was shown to significantly improve the mechanical properties of the gelatin foam. Both compressive modulus and ultimate strength was found to increase over 10 times when the modular design was employed. The bio-reactive module i.e., gelatin foam, presented a dual porosity network of 100-300 μm primary and <10 μm secondary pores. SEM images revealed excellent attachment of DPSCs to the bio-reactive module.
本研究开发并表征了一种模块化设计，该设计由3D打印的聚己内酯（PCL）作为承重模块和双孔隙率明胶泡沫作为生物反应模块组成。研究发现，通过氨解-醛工艺对PCL模块进行表面处理，与NaOH水解相比，可产生更强的界面结合，因此用于制造过程。模块化支架显示出显著改善了明胶泡沫的力学性能。当采用模块化设计时，压缩模量和极限强度均增加了10倍以上。生物反应模块，即明胶泡沫，呈现出100-300μm的初级孔和<10μm的次级孔的双孔隙网络。扫描电子显微镜图像显示牙髓干细胞与生物反应模块有良好的附着。
