Cho Yong Sang, Gwak So-Jung, Cho Young-Sam
Medical IT Convergence Research Section, Daegu-Gyeongbuk Research Center, Electronics and Telecommunications Research Institute (ETRI), Techno Sunhwan-ro 10-gil, Dalseong-gun, Daegu 42994, Korea.
Department of Chemical Engineering, College of Engineering, Wonkwang University, 460 Iksandae-ro, Iksan, Jeonbuk 54538, Korea.
Polymers (Basel). 2021 Apr 25;13(9):1394. doi: 10.3390/polym13091394.
In this study, we investigated the dual-pore kagome-structure design of a 3D-printed scaffold with enhanced in vitro cell response and compared the mechanical properties with 3D-printed scaffolds with conventional or offset patterns. The compressive modulus of the 3D-printed scaffold with the proposed design was found to resemble that of the 3D-printed scaffold with a conventional pattern at similar pore sizes despite higher porosity. Furthermore, the compressive modulus of the proposed scaffold surpassed that of the 3D-printed scaffold with conventional and offset patterns at similar porosities owing to the structural characteristics of the kagome structure. Regarding the in vitro cell response, cell adhesion, cell growth, and ALP concentration of the proposed scaffold for 14 days was superior to those of the control group scaffolds. Consequently, we found that the mechanical properties and in vitro cell response of the 3D-printed scaffold could be improved by kagome and dual-pore structures through DfAM. Moreover, we revealed that the dual-pore structure is effective for the in vitro cell response compared to the structures possessing conventional and offset patterns.
在本研究中，我们研究了具有增强体外细胞反应的3D打印支架的双孔戈薇结构设计，并将其力学性能与具有传统或偏移图案的3D打印支架进行了比较。尽管孔隙率较高，但发现具有所提出设计的3D打印支架的压缩模量在相似孔径下与具有传统图案的3D打印支架相似。此外，由于戈薇结构的结构特性，所提出支架的压缩模量在相似孔隙率下超过了具有传统和偏移图案的3D打印支架。关于体外细胞反应，所提出支架14天的细胞粘附、细胞生长和碱性磷酸酶浓度优于对照组支架。因此，我们发现通过数字增材制造（DfAM），戈薇和双孔结构可以改善3D打印支架的力学性能和体外细胞反应。此外，我们还发现，与具有传统和偏移图案的结构相比，双孔结构对体外细胞反应有效。
