Wu Fanqi, Zhang Longguo, Wu Pingfan, Wu Yi, Zhang Tao, Zhang Dekui, Tian Jinhui
Department of Respiratory, Lanzhou University Second Hospital, Lanzhou, Gansu Province, People's Republic of China.
The Second Clinical Medical School, Lanzhou University, Lanzhou, Gansu Province, People's Republic of China.
Int J Gen Med. 2022 Apr 8;15:3851-3864. doi: 10.2147/IJGM.S352333. eCollection 2022.
Cancer seriously endangers human health in every country of the world. New evidence shows that small nucleolar RNAs play important roles in tumorigenesis. Herein, we created this evidence map to systematically assess the impact of dysregulated snoRNAs on cancers.
We searched four databases to February 2022 using the keywords, "carcinoma", "neoplasms", "tumor", "cancer", "snoRNA", and "small nucleolar rna". The research data were independently screened by two reviewers. Bubble plot, mind map, heatmap were used to depict the relationship between snoRNAs and cancers.
In total, 102 studies met the inclusion criteria and were analyzed in this evidence map. In this study, we found that dysregulated snoRNAs were statistically associated with the clinicopathological characteristics of cancer patients, and affected tumor cell phenotypes. Abnormally expressed snoRNAs were associated with poor survival in cancer patients. Current research confirmed that snoRNAs have good diagnostic efficiency for cancers. snoRNAs could modulate biological processes and signaling pathways of different cancer cells by altering rRNA, regulating mRNA, and recruiting protein factors.
Taken all together, ectopic snoRNAs may serve as new biomarkers for clinical assessment, diagnostic, prognostic prediction of cancer patients, and provide a potential therapeutic strategy for cancer treatment. This article provided a visual analysis of existing evidence on snoRNAs and cancers, which can offer useful information for different researchers interested in snoRNAs.
癌症在世界各国都严重危害人类健康。新证据表明，小核仁RNA在肿瘤发生中起重要作用。在此，我们创建了这一证据图谱，以系统评估失调的小核仁RNA对癌症的影响。
我们使用关键词“癌”“肿瘤”“瘤”“癌症”“小核仁RNA”和“small nucleolar rna”在四个数据库中检索截至2022年2月的数据。研究数据由两名审阅者独立筛选。采用气泡图、思维导图、热图来描绘小核仁RNA与癌症之间的关系。
共有102项研究符合纳入标准，并在本证据图谱中进行了分析。在本研究中，我们发现失调的小核仁RNA与癌症患者的临床病理特征在统计学上相关，并影响肿瘤细胞表型。异常表达的小核仁RNA与癌症患者的不良生存相关。目前的研究证实，小核仁RNA对癌症具有良好的诊断效率。小核仁RNA可通过改变核糖体RNA、调节信使RNA和招募蛋白质因子来调节不同癌细胞的生物学过程和信号通路。
综上所述，异位小核仁RNA可能作为癌症患者临床评估、诊断、预后预测的新生物标志物，并为癌症治疗提供潜在的治疗策略。本文对小核仁RNA与癌症的现有证据进行了可视化分析，可为对小核仁RNA感兴趣的不同研究人员提供有用信息。
