Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States.
Cell Biology Lab, Division of Virology, Pathogenesis and Cancer, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States.
Front Immunol. 2022 Apr 1;13:859654. doi: 10.3389/fimmu.2022.859654. eCollection 2022.
The report is not a review or a summary. In a manner, it is a perspective but an unusual one. It looks back to the years my colleagues and I (RG) began preparing for human retroviruses (beginning in 1970), how they evolved, and attempts to bring to light or simply to emphasize many exceptional characteristics of a retrovirus known as HTLV-1 and some fortuitous coincidences, with emphasis on the needs of the field. These events cover over one half a century. We have had many reviews on HTLV-1 disease, epidemiology, and basic aspects of its replication, genome, gene functions, structure, and pathogenesis, though continued updates are needed. However, some of its truly exceptional features have not been highlighted, or at least not in a comprehensive manner. This article attempts to do so.
该报告不是一篇综述或总结。在某种程度上，它是一种观点，但却是一种不寻常的观点。它回顾了我和我的同事们（RG）开始为人类逆转录病毒做准备的那些年（始于 1970 年），回顾了它们是如何演变的，并试图揭示或仅仅强调一种名为 HTLV-1 的逆转录病毒的许多特殊特性，以及一些偶然的巧合，重点是该领域的需求。这些事件跨越了半个多世纪。我们已经有很多关于 HTLV-1 疾病、流行病学以及其复制、基因组、基因功能、结构和发病机制的基础方面的综述，尽管需要不断更新。然而，它的一些真正特殊的特征并没有被突出强调，或者至少没有以全面的方式强调。本文试图这样做。
