鸭乙型肝炎病毒感染鸭的体液免疫反应性

Halpern M S, Mason W S, Coates L, O'Connell A P, England J M

J Virol. 1987 Mar;61(3):916-20. doi: 10.1128/JVI.61.3.916-920.1987.

Immunofluorescence assays with fixed tissue sections were used to characterize antibody reactivity in sera obtained from duck hepatitis B virus-infected ducks. Under conditions of experimental infection, antibody to core antigen but not to surface antigen was detectable. A majority of the ducks infected at 8 days after hatching and a minority of those infected at 1 day after hatching showed a transient anti-core antigen humoral response; this response was stronger in the antibody-positive ducks infected on day 8 than in those infected on day 1. Antiviral antibody was not detected in the sera of ducks congenitally infected with duck hepatitis B virus. Several of the infected ducks, but none of the uninfected ducks, exhibited autoantibody reactivity for alpha-islet-cell-associated antigen.

使用固定组织切片的免疫荧光测定法来表征从感染鸭乙型肝炎病毒的鸭子获得的血清中的抗体反应性。在实验感染条件下，可检测到针对核心抗原而非表面抗原的抗体。大多数在孵化后8天感染的鸭子和少数在孵化后1天感染的鸭子表现出短暂的抗核心抗原体液反应；这种反应在8天感染的抗体阳性鸭子中比在1天感染的鸭子中更强。在先天性感染鸭乙型肝炎病毒的鸭子血清中未检测到抗病毒抗体。几只感染的鸭子，但未感染的鸭子均未表现出对α-胰岛细胞相关抗原的自身抗体反应性。