Ufa Eye Research Institute, 90 Pushkin Street, Ufa, Bashkortostan, 450077, Russia.
Ufa Eye Institute, Ufa, Russia.
Sci Rep. 2022 Jul 23;12(1):12607. doi: 10.1038/s41598-022-16925-6.
To determine the prevalence of osteoarthritis and its associated factors in populations from Russia. The population-based Ural Eye and Medical Study (UEMS) and the population-based Ural Very Old Study (UVOS) were conducted in a rural and urban region in Bashkortostan/Russia and included participants aged 40+ and 85+ years, respectively. As part of a detailed systematic examination, we assessed the osteoarthritis prevalence in an interview including questions on the self-reported presence of osteoarthritis, the joints affected and osteoarthritis-related pain-relieving therapy taken. Out of 5898 participants of the UEMS, 1636 individuals had osteoarthritis [prevalence: 27.7%; 95% confidence interval (CI) 26.7, 28.7], with 816 individuals (13.8%; 95% CI 12.8, 14.8) taking pain-relieving medication. A higher osteoarthritis prevalence was associated (multivariable analysis) with older age [odds ratio (OR 1.04; 95% confidence interval (CI) 1.03, 1.05], urban region of residence (OR 1.25; 95% CI 1.07, 1.45), higher body mass index (BMI) (OR 1.04; 95% CI 1.03, 1.06), lower monthly income (OR 0.78; 95% CI 0.68, 0.90), higher physical activity score (OR 1.02, 95% CI 1.01, 1.03), higher prevalence of a history of cardiovascular disease including stroke (OR 1.55; 95% CI 1.33, 1.81), previous bone fractures (OR 1.20; 95% CI 1.04, 1.40) and previous falls (OR 1.22; 95% CI 1.03, 1.45), higher hearing loss score (OR 1.01; 95% CI 1.01, 1.02), and less alcohol consumption (OR 0.78; 95% CI 0.65, 0.93). Out of 1526 UVOS participants, 567 individuals had osteoarthritis (prevalence: 37.2%; 95% CI 35.0, 40.0), with 195 (12.8%; 95% CI 11.3, 14.3) individuals taking pain-relieving medication. Higher osteoarthritis prevalence was associated with rural region of habitation (OR 1.69; 95% CI 1.20, 2.38), lower monthly income (OR 0.62; 95% CI 0.46, 0.84), higher prevalence of cardiovascular disease (OR 1.75; 95% CI 1.30, 2.36), and higher anxiety score (OR 1.04; 95% CI 1.03, 1.06). Osteoarthritis and use of pain-relieving medication are common in these populations in Russia. Main associated factors were older age and lower monthly income in both study populations, female sex, higher BMI, urban region, and previous falls and bone fractures in the UEMS population, and rural region and a higher anxiety score in the UVOS study population.
为了确定俄罗斯人群中骨关节炎及其相关因素的患病率。这项基于人群的乌拉尔眼科和医学研究（UEMS）和基于人群的乌拉尔老年研究（UVOS）分别在俄罗斯巴什科尔托斯坦的农村和城市地区进行，纳入了 40 岁及以上和 85 岁及以上的参与者。作为详细系统检查的一部分，我们在访谈中评估了骨关节炎的患病率，包括自我报告的骨关节炎存在、受影响的关节和服用的骨关节炎缓解疼痛的治疗方法。在 UEMS 的 5898 名参与者中，有 1636 人患有骨关节炎[患病率：27.7%；95%置信区间（CI）26.7%，28.7%]，其中 816 人（13.8%；95%CI 12.8%，14.8%）服用了止痛药。多变量分析显示，骨关节炎的患病率与年龄较大（比值比[OR]1.04；95%CI 1.03，1.05）、居住在城市地区（OR 1.25；95%CI 1.07，1.45）、较高的身体质量指数（BMI）（OR 1.04；95%CI 1.03，1.06）、较低的月收入（OR 0.78；95%CI 0.68，0.90）、较高的体力活动评分（OR 1.02；95%CI 1.01，1.03）、较高的心血管疾病史（包括中风）的患病率（OR 1.55；95%CI 1.33，1.81）、既往骨骨折（OR 1.20；95%CI 1.04，1.40）和既往跌倒（OR 1.22；95%CI 1.03，1.45）、听力损失评分较高（OR 1.01；95%CI 1.01，1.02）、饮酒量较少（OR 0.78；95%CI 0.65，0.93）有关。在 1526 名 UVOS 参与者中，有 567 人患有骨关节炎（患病率：37.2%；95%CI 35.0%，40.0%），其中 195 人（12.8%；95%CI 11.3%，14.3%）服用了止痛药。骨关节炎的患病率与农村地区居住（OR 1.69；95%CI 1.20，2.38）、较低的月收入（OR 0.62；95%CI 0.46，0.84）、较高的心血管疾病患病率（OR 1.75；95%CI 1.30，2.36）和较高的焦虑评分（OR 1.04；95%CI 1.03，1.06）有关。骨关节炎和止痛药的使用在俄罗斯的这些人群中很常见。两个研究人群的主要相关因素均为年龄较大和月收入较低，女性、较高的 BMI、城市地区、既往跌倒和骨折在 UEMS 人群中，农村地区和较高的焦虑评分在 UVOS 研究人群中。
