Institute for Global Health, University College London, London, UK.
UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
BMC Health Serv Res. 2022 Apr 19;22(1):518. doi: 10.1186/s12913-022-07901-x.
Paediatric patients being treated for long-term physical health conditions (LTCs) have elevated mental health needs. However, mental health services in the community are difficult to access in the usual course of care for these patients. The Lucy Project - a self-referral drop-in access point-was a program to address this gap by enrolling patients for low-intensity psychological interventions during their treatment for LTCs. In this paper, we evaluate the cost-effectiveness of the Lucy Project.
Using a pre-post design, we evaluate the cost-effectiveness of the intervention by calculating the base-case incremental cost-effectiveness ratio (ICER) using outcomes data and expenses recorded by project staff. The target population was paediatric patients enrolled in the program with an average age of 9 years, treated over a time horizon of 6 months. Outcome data were collected via the Paediatric Quality of Life Inventory, which was converted to health utility scores using an instrument found in the literature. The QALYs were estimated using these health utility scores and the length of the intervention. We calculate a second, practical-case incremental cost-effectiveness ratio using streamlined costing figures with maximum capacity patient enrolment within a one-year time horizon, and capturing lessons learned post-trial.
The base-case model showed an ICER of £21,220/Quality Adjusted Life Years (QALY) gained, while the practical model showed an ICER of £4,359/QALY gained. The practical model suggests the intervention garners significant gains in quality of life at an average cost of £309 per patient. Sensitivity analyses reveal use of staff time was the greatest determinant of the ICER, and the intervention is cost-effective 75% of the time in the base-case model, and 94% of the time in the practical-case model at a cost-effectiveness threshold of £20,000/QALY gained.
We find the base-case intervention improves patient outcomes and can be considered cost-effective according to the National Institute for Health and Care Excellence (NICE) threshold of £20,000-£30,000/QALY gained, and the practical-case intervention is roughly four times as cost-effective as the base-case. We recommend future studies incorporate a control group to corroborate the effect size of the intervention.
接受长期身体疾病治疗的儿科患者存在较高的心理健康需求。然而,在这些患者的常规治疗过程中,社区心理健康服务难以获得。露西项目——一个自我转诊的即到即诊服务点——旨在通过在治疗长期疾病的过程中为患者提供低强度的心理干预来填补这一空白。在本文中,我们评估了露西项目的成本效益。
使用前后设计,我们通过计算项目工作人员记录的结果数据和费用来计算干预措施的基本情况增量成本效益比 (ICER),评估干预措施的成本效益。目标人群是参加该项目的平均年龄为 9 岁的儿科患者,治疗时间为 6 个月。结果数据通过儿科生活质量量表收集,并使用文献中发现的工具转换为健康效用评分。使用这些健康效用评分和干预措施的长度来估计 QALYs。我们使用最大容量的患者入组,在一年的时间内,以及在试验后吸取经验,计算了第二个实用案例增量成本效益比。
基本案例模型显示,每获得一个质量调整生命年 (QALY) 的成本为 21220 英镑,而实用案例模型显示,每获得一个 QALY 的成本为 4359 英镑。实用案例模型表明,该干预措施在平均每位患者 309 英镑的成本下,显著提高了生活质量。敏感性分析表明,员工时间的使用是决定 ICER 的最大因素,在基本案例模型中,该干预措施在 75%的时间内具有成本效益,在实用案例模型中在 94%的时间内具有成本效益,在每获得一个 QALY 的成本效益阈值为 20000 英镑时。
我们发现,根据英国国家卫生与临床优化研究所 (NICE) 每获得一个 QALY 的成本效益阈值为 20000-30000 英镑,基本案例干预措施改善了患者的预后,并且可以被认为是具有成本效益的,而实用案例干预措施的成本效益是基本案例的大约四倍。我们建议未来的研究纳入对照组,以证实干预措施的效果大小。