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动态心脏细胞景观：分子成像可视化。

The dynamic cardiac cellular landscape: visualization by molecular imaging.

机构信息

Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.

出版信息

Nat Rev Cardiol. 2022 Jun;19(6):345-347. doi: 10.1038/s41569-022-00702-z.

DOI:10.1038/s41569-022-00702-z
PMID:35440737
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9793332/
Abstract

Paradigm shifting studies have unveiled that the heart contains heterogeneous and dynamic immune and stromal cell populations that serve as critical determinants of health and disease. Advances in molecular imaging now make it possible to non-invasively visualize the cardiac landscape in humans and provide a means to guide precision therapies.

摘要

具有开创性意义的研究揭示，心脏中存在异质性和动态的免疫细胞和基质细胞群体，这些群体是健康和疾病的关键决定因素。分子成像技术的进步现在使得在人体中无创可视化心脏图谱成为可能，并为精准治疗提供了一种手段。

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Nat Cardiovasc Res. 2022 Mar;1(3):263-280. doi: 10.1038/s44161-022-00028-6. Epub 2022 Mar 16.
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Cardiac Fibroblast Activation in Patients Early After Acute Myocardial Infarction: Integration with MR Tissue Characterization and Subsequent Functional Outcome.急性心肌梗死后早期患者的心肌成纤维细胞激活：与 MR 组织特征分析及随后的功能预后的整合。
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Exploring cardiac macrophage heterogeneity in the healthy and diseased myocardium.探索健康和患病心肌中心巨噬细胞的异质性。
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Relationship Between Cardiac Fibroblast Activation Protein Activity by Positron Emission Tomography and Cardiovascular Disease.正电子发射断层扫描心肌成纤维细胞激活蛋白活性与心血管疾病的关系。
Circ Cardiovasc Imaging. 2020 Sep;13(9):e010628. doi: 10.1161/CIRCIMAGING.120.010628. Epub 2020 Sep 11.
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Molecular imaging-guided repair after acute myocardial infarction by targeting the chemokine receptor CXCR4.通过靶向趋化因子受体CXCR4实现急性心肌梗死后的分子成像引导修复
Eur Heart J. 2020 Oct 1;41(37):3564-3575. doi: 10.1093/eurheartj/ehaa598.
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Targeted PET Imaging of Chemokine Receptor 2-Positive Monocytes and Macrophages in the Injured Heart.靶向趋化因子受体 2 阳性单核细胞和巨噬细胞在损伤心脏中的 PET 成像。
J Nucl Med. 2021 Jan;62(1):111-114. doi: 10.2967/jnumed.120.244673. Epub 2020 May 22.
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