Cheng Keren, Seita Yasunari, Moriwaki Taku, Noshiro Kiwamu, Sakata Yuka, Hwang Young Sun, Torigoe Toshihiko, Saitou Mitinori, Tsuchiya Hideaki, Iwatani Chizuru, Hosaka Masayoshi, Ohkouchi Toshihiro, Watari Hidemichi, Umazume Takeshi, Sasaki Kotaro
Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sci Adv. 2022 Apr 22;8(16):eabn8485. doi: 10.1126/sciadv.abn8485. Epub 2022 Apr 20.
Development of the adrenal cortex, a vital endocrine organ, originates in the adrenogonadal primordium, a common progenitor for both the adrenocortical and gonadal lineages in rodents. In contrast, we find that in humans and cynomolgus monkeys, the adrenocortical lineage originates in a temporally and spatially distinct fashion from the gonadal lineage, arising earlier and more anteriorly within the coelomic epithelium. The adrenal primordium arises from adrenogenic coelomic epithelium via an epithelial-to-mesenchymal transition, which then progresses into the steroidogenic fetal zone via both direct and indirect routes. Notably, we find that adrenocortical and gonadal lineages exhibit distinct HOX codes, suggesting distinct anterior-posterior regionalization. Together, our assessment of the early divergence of these lineages provides a molecular framework for understanding human adrenal and gonadal disorders.
肾上腺皮质作为一个重要的内分泌器官，其发育起源于肾上腺性腺原基，这是啮齿动物肾上腺皮质和性腺谱系的共同祖细胞。相比之下，我们发现，在人类和食蟹猴中，肾上腺皮质谱系在时间和空间上与性腺谱系以不同的方式起源，在体腔上皮中出现得更早且更靠前。肾上腺原基通过上皮-间充质转化从肾上腺生成性体腔上皮产生，然后通过直接和间接途径发展为类固醇生成胎儿带。值得注意的是，我们发现肾上腺皮质和性腺谱系表现出不同的HOX编码，表明存在不同的前后区域化。总之，我们对这些谱系早期分化的评估为理解人类肾上腺和性腺疾病提供了一个分子框架。
