Could the Thyroid Gland Dominate the Brain in Obsessive-Compulsive Disorder?

Thyroid hormones have an essential role in brain maturation and neuronal functioning. The comorbidity of thyroid disorders and several mental disturbances is frequently reported. We aimed to evaluate the literature on the potential relationship between thyroid disorders and obsessive-compulsive disorder (OCD) and obsessive-compulsive symptoms (OCS). We searched the literature using PUBMED, ProQuest, Google Scholar, and PsycInfo electronic databases for original studies (cross-sectional, case series, case report) on the association between thyroid dysfunctions and OCD and OCS between 1977 and 2021. Eleven studies met the inclusion criteria. Despite some methodological limitations, the OCD rates in patients with autoimmune thyroid disorders were found to be higher than the normal population in two studies. The findings on thyroid dysfunction in OCD patients were inconclusive. In the light of available data, it could be proposed that there might be a possible association between thyroid disorders and OCD. Some shared immunological mechanisms could play a role in the pathophysiology of both thyroid diseases and OCD. New research is needed to confirm this association and elucidate the underlying common mechanisms between these disorders.