Department of Psychiatry, Ankara Yildirim Beyazit University, Ankara, Turkey.
Department of Psychiatry, Ankara Dr. Abdurrahman Yurtaslan Oncology Research and Training Hospital, Health Science University, Ankara, Turkey.
Neuroendocrinology. 2022;112(12):1143-1154. doi: 10.1159/000524627. Epub 2022 Apr 20.
Thyroid hormones have an essential role in brain maturation and neuronal functioning. The comorbidity of thyroid disorders and several mental disturbances is frequently reported. We aimed to evaluate the literature on the potential relationship between thyroid disorders and obsessive-compulsive disorder (OCD) and obsessive-compulsive symptoms (OCS). We searched the literature using PUBMED, ProQuest, Google Scholar, and PsycInfo electronic databases for original studies (cross-sectional, case series, case report) on the association between thyroid dysfunctions and OCD and OCS between 1977 and 2021. Eleven studies met the inclusion criteria. Despite some methodological limitations, the OCD rates in patients with autoimmune thyroid disorders were found to be higher than the normal population in two studies. The findings on thyroid dysfunction in OCD patients were inconclusive. In the light of available data, it could be proposed that there might be a possible association between thyroid disorders and OCD. Some shared immunological mechanisms could play a role in the pathophysiology of both thyroid diseases and OCD. New research is needed to confirm this association and elucidate the underlying common mechanisms between these disorders.
甲状腺激素在大脑成熟和神经元功能中起着至关重要的作用。甲状腺疾病与多种精神障碍的共病经常被报道。我们旨在评估关于甲状腺疾病与强迫症（OCD）和强迫症状（OCS）之间潜在关系的文献。我们使用 PUBMED、ProQuest、Google Scholar 和 PsycInfo 电子数据库，检索了 1977 年至 2021 年间关于甲状腺功能障碍与 OCD 和 OCS 之间关联的原始研究（横断面研究、病例系列研究、病例报告）。有 11 项研究符合纳入标准。尽管存在一些方法学限制，但两项研究发现自身免疫性甲状腺疾病患者的 OCD 发生率高于正常人群。关于 OCD 患者甲状腺功能障碍的研究结果尚无定论。根据现有数据，可以提出甲状腺疾病与 OCD 之间可能存在关联。一些共同的免疫机制可能在甲状腺疾病和 OCD 的病理生理学中起作用。需要进一步的研究来证实这种关联，并阐明这些疾病之间的潜在共同机制。
