O'Shea Deirdre M, de Wit Liselotte, Tanner Jared, Mejia Kurasz Andrea, Amofa Priscilla, Perez Lao Ambar, Levy Shellie-Anne, Chandler Melanie, Smith Glenn
Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Arch Clin Neuropsychol. 2022 Oct 19;37(7):1502-1514. doi: 10.1093/arclin/acac018.
Evidence suggests that select hippocampal subfields are implicated in the initial stages of Alzheimer's disease (AD) and are selectively involved in objective memory. Less is known whether subfields are associated with informant-reported memory difficulties of individuals with a diagnosis of mild cognitive impairment (MCI).
Data from 56 participants with a diagnosis of amnestic MCI were included in the present study. To test whether FreeSurfer derived hippocampal subfields (CA1-4, subiculum, presubiculum, and dentate gyrus) were associated with objective (learning and delayed recall) and informant-reports of memory difficulties, we used multiple linear regression analysis. Subfields were adjusted for total intracranial volume, and age, sex, and years of education were included as covariates in all models.
Larger presubiculum, subiculum, and CA4/dentate gyrus volumes were associated with higher delayed recall scores, and larger subiculum and CA4/dentate gyrus volumes were associated with fewer informant-reports of memory difficulties. There were no statistically significant associations between subfields and learning scores.
Findings from the present study support the idea that difficulties with memory-dependent everyday tasks in older adults with MCI may signal a neurodegenerative process while increasing understanding of subfields correlates of these memory-specific functional difficulties. Continued investigations into identifying patterns of subfield atrophy in AD may aid early identification of those at higher risk of dementia conversion while advancing precision medicine.
有证据表明，特定的海马亚区与阿尔茨海默病（AD）的初始阶段有关，并且选择性地参与客观记忆。对于这些亚区是否与诊断为轻度认知障碍（MCI）的个体的知情者报告的记忆困难相关，人们了解较少。
本研究纳入了56名诊断为遗忘型MCI的参与者的数据。为了测试FreeSurfer得出的海马亚区（CA1 - 4、海马下脚、前海马下脚和齿状回）是否与客观记忆（学习和延迟回忆）以及记忆困难的知情者报告相关，我们使用了多元线性回归分析。亚区体积以总颅内体积进行校正，年龄、性别和受教育年限在所有模型中作为协变量纳入。
前海马下脚、海马下脚和CA4/齿状回体积较大与较高的延迟回忆分数相关，海马下脚和CA4/齿状回体积较大与记忆困难的知情者报告较少相关。亚区与学习分数之间没有统计学上的显著关联。
本研究结果支持这样一种观点，即患有MCI的老年人在依赖记忆的日常任务中出现困难可能预示着神经退行性过程，同时增加了对这些记忆特定功能困难的亚区相关性的理解。继续研究确定AD中亚区萎缩模式可能有助于早期识别痴呆转化风险较高的人群，同时推动精准医学发展。
