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The Double-Edged Sword: Are Endocannabinoids Doing More Harm than Good in Epilepsy?

作者信息

Boublil Brittney L, Ewell Laura A

出版信息

Epilepsy Curr. 2021 Dec 8;22(2):139-140. doi: 10.1177/15357597211062412. eCollection 2022 Mar-Apr.

DOI:10.1177/15357597211062412
PMID:35444504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8988730/
Abstract
摘要

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本文引用的文献

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In vivo endocannabinoid dynamics at the timescale of physiological and pathological neural activity.体内神经活动生理和病理时间尺度上的内源性大麻素动态。
Neuron. 2021 Aug 4;109(15):2398-2403.e4. doi: 10.1016/j.neuron.2021.05.026.
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Postictal behavioural impairments are due to a severe prolonged hypoperfusion/hypoxia event that is COX-2 dependent.发作后行为障碍是由于严重且持续时间较长的低灌注/缺氧事件引起的,该事件依赖于 COX-2。
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Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of Epileptic Seizures.内源性大麻素2-花生四烯酸甘油酯在抑制癫痫发作中的关键作用
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Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy.剔除不良电波:迈向癫痫中选择性大麻素环路控制
Nat Rev Neurosci. 2015 May;16(5):264-77. doi: 10.1038/nrn3937.
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Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.大麻二酚:药理学及在癫痫和其他神经精神疾病中的潜在治疗作用。
Epilepsia. 2014 Jun;55(6):791-802. doi: 10.1111/epi.12631. Epub 2014 May 22.
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Prostaglandin E2, a postulated astrocyte-derived neurovascular coupling agent, constricts rather than dilates parenchymal arterioles.前列腺素 E2,一种假定的星形胶质细胞衍生的神经血管耦合剂,收缩而不是扩张实质小动脉。
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Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia.大麻二酚增强了内源性大麻素信号传导,并缓解了精神分裂症的精神病症状。
Transl Psychiatry. 2012 Mar 20;2(3):e94. doi: 10.1038/tp.2012.15.
8
Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation.内源性大麻素水解产生促进神经炎症的脑前列腺素。
Science. 2011 Nov 11;334(6057):809-13. doi: 10.1126/science.1209200. Epub 2011 Oct 20.
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In vivo activation of endocannabinoid system in temporal lobe epilepsy with hippocampal sclerosis.内侧颞叶癫痫伴海马硬化症中内源性大麻素系统的体内激活。
Brain. 2011 Apr;134(Pt 4):1033-40. doi: 10.1093/brain/awq385. Epub 2011 Feb 8.
10
CB1 cannabinoid receptors and on-demand defense against excitotoxicity.CB1大麻素受体与针对兴奋性毒性的按需防御。
Science. 2003 Oct 3;302(5642):84-8. doi: 10.1126/science.1088208.