宫颈癌的分子病理机制（基质金属蛋白酶1）
Molecular Patho-mechanisms of cervical cancer (MMP1).
作者信息
Kurnia Iwan, Rauf Syahrul, Hatta Mochammad, Arifuddin Sharvianty, Hidayat Yudi Maulana, Natzir Rosdiana, Kaelan Cahyo, Bukhari Agussalim, Pelupessy Nugraha Utama, Patelonggi Ilham Jaya
机构信息
Department of Obstetrics and Gynaecology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Department of Molecular Biology and Immunology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
出版信息
Ann Med Surg (Lond). 2022 Mar 31;77:103415. doi: 10.1016/j.amsu.2022.103415. eCollection 2022 May.
Cervical cancer mostly caused by Human Papilloma Virus. Staging and therapy have been extensively studied, and highly correlated with the cellular development of oncogenesis. Mutation was caused by E6 and E7 oncoprotein, also inactivation of 2 tumor suppressor factors (pRB and p53). P53 also regulated MMP1, which dysregulation of MMP transcription would promote tumor metastasis, because of its role in extracellular matrix degradation in tumor invasion. Clinical staging of Cervical Cancer was based on (FIGO) classification from 2018. Management was divided into Surgery, Radiotherapy, and Chemotherapy.
宫颈癌主要由人乳头瘤病毒引起。其分期和治疗已得到广泛研究，且与肿瘤发生的细胞发展高度相关。突变由E6和E7癌蛋白引起，同时导致两种肿瘤抑制因子（pRB和p53）失活。p53还调节基质金属蛋白酶1（MMP1），MMP转录失调会促进肿瘤转移，因为它在肿瘤侵袭过程中参与细胞外基质降解。宫颈癌的临床分期基于2018年国际妇产科联盟（FIGO）分类。治疗方法分为手术、放疗和化疗。
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